Neutrophil to lymphocyte ratio predicting poor outcome after aneurysmal subarachnoid hemorrhage: A retrospective study and updated meta-analysis.
Neutrophil to lymphocyte ratio predicting poor outcome after aneurysmal subarachnoid hemorrhage: A retrospective study and updated meta-analysis.
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中性粒细胞与淋巴细胞的比率预测动脉瘤性蛛网膜下腔出血后的不良预后：一项回顾性研究和更新的荟萃分析。
DOI：
10.3389/fimmu.2022.962760
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发表时间：
2022
影响因子：
7.3
通讯作者：
Chen, Gao
中科院分区：
文献类型：
--
作者：
Guo, Yinghan;Liu, Jiang;Zeng, Hanhai;Cai, Lingxin;Wang, Tingting;Wu, Xinyan;Yu, Kaibo;Zheng, Yonghe;Chen, Huaijun;Peng, Yucong;Yu, Xiaobo;Yan, Feng;Cao, Shenglong;Chen, Gao
关键词：
中性粒细胞与淋巴细胞比值（NLR）与蛛网膜下腔出血（aSAH）预后不良的关系存在争议。我们的目的是评估入院时NLR与aSAH后不良结局之间的关系。第一部分：回顾性分析本中心aSAH患者。收集并比较患者的基线特征。多变量分析用于评估与不良结局独立相关的参数。采用受试者工作特征（ROC）曲线分析确定NLR的最佳临界值。第二部分：相关文献的系统综述和荟萃分析。通过数据库检索相关文献。计算合并比值比（OR）和相应的95%置信区间（CI），以评估NLR与结局指标之间的相关性。第一部分：共入组240例aSAH患者，其中52例患者结局不佳。3个月时预后差的患者有较高的入院NLR、Hunt & Hess评分、巴罗神经学研究所（BNI）量表评分、蛛网膜下腔出血早期脑水肿评分（SEBES）和高血压病史比例。调整后，入院时NLR仍是aSAH患者预后不良的独立预测因素（OR 0.76，95%CI 0.69-0.83; P < 0.001）。ROC分析中NLR的最佳截断值为12.03（曲线下面积0.805，95% CI 0.735 ~ 0.875; P < 0.001）。第二部分：共纳入16篇文献。汇总结果显示，NLR升高与不良结局（OR 1.31，95%CI 1.14-1.49; P < 0.0001）和迟发性脑缺血（DCI）发生（OR 1.32，95%CI 1.11-1.56; P = 0.002）显著相关。在大样本量、低NLR临界值、多中心或前瞻性研究中，结果更可靠。NLR升高是aSAH患者预后不良和DCI发生的独立预测因子。
The relationship between neutrophil to lymphocyte ratio (NLR) and poor outcome of aneurysmal subarachnoid hemorrhage (aSAH) is controversial. We aim to evaluate the relationship between NLR on admission and the poor outcome after aSAH. Part I: Retrospective analysis of aSAH patients in our center. Baseline characteristics of patients were collected and compared. Multivariate analysis was used to evaluate parameters independently related to poor outcome. Receiver operating characteristic (ROC) curve analysis was used to determine the best cut-off value of NLR. Part II: Systematic review and meta-analysis of relevant literature. Related literature was selected through the database. The pooled odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated to evaluate the correlation between NLR and outcome measures. Part I: A total of 240 patients with aSAH were enrolled, and 52 patients had a poor outcome. Patients with poor outcome at 3 months had a higher admission NLR, Hunt & Hess score, Barrow Neurological Institute (BNI) scale score, Subarachnoid Hemorrhage Early Brain Edema Score (SEBES), and proportion of hypertension history. After adjustment, NLR at admission remained an independent predictor of poor outcome in aSAH patients (OR 0.76, 95% CI 0.69-0.83; P < 0.001). The best cut-off value of NLR in ROC analysis is 12.03 (area under the curve 0.805, 95% CI 0.735 - 0.875; P < 0.001). Part II: A total of 16 literature were included. Pooled results showed that elevated NLR was significantly associated with poor outcome (OR 1.31, 95% CI 1.14-1.49; P < 0.0001) and delayed cerebral ischemia (DCI) occurrence (OR 1.32, 95% CI 1.11-1.56; P = 0.002). The results are more reliable in large sample sizes, low NLR cut-off value, multicenter, or prospective studies. Elevated NLR is an independent predictor of poor outcome and DCI occurrence in aSAH.
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影响因子：
3.4
作者：
Gusdon AM;Savarraj JPJ;Shihabeddin E;Paz A;Assing A;Ko SB;McCullough LD;Choi HA
通讯作者：
Choi HA
影响因子：
4.8
作者：
Geraghty, Joseph R.;Lung, Tyler J.;Testai, Fernando D.
通讯作者：
Testai, Fernando D.
影响因子：
2
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Ignacio, Katrina Hannah D.;Diestro, Jose Danilo B.;Legaspi, Gerardo D.
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Legaspi, Gerardo D.
脑脊液中性粒细胞与蛛网膜下腔出血中血管痉挛的发生有关。
影响因子：
3.5
作者：
Provencio, J. J.;Fu, X.;Siu, A.;Rasmussen, P. A.;Hazen, S. L.;Ransohoff, R. M.
通讯作者：
Ransohoff, R. M.
影响因子：
6.1
作者：
Chen Y;Lian BQ;Peng L;Ding CY;Lin YX;Yu LH;Wang DL;Kang DZ
通讯作者：
Kang DZ