Multiphoton autofluorescence microscopy and second harmonic generation microscopy of oral epithelial neoplasms.
Multiphoton autofluorescence microscopy and second harmonic generation microscopy of oral epithelial neoplasms.
复制标题
口腔上皮肿瘤的多光子自发荧光显微镜和二次谐波发生显微镜。
DOI：
10.1109/iembs.2009.5332783
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
McCammon,Susan
中科院分区：
文献类型：
--
作者：
Vargas,Gracie;Shilagard,Tuya;Ho,Ki-Hong;McCammon,Susan
本研究的目的是评价非线性光学显微镜技术多光子自体荧光显微镜（MPAM）和二次谐波发生显微镜（SHGM）在口腔上皮癌发生中的无创成像。在口腔癌变的仓鼠模型中进行了体内成像，以表征肿瘤转化过程中的光学和形态学改变。数据显示在肿瘤转化的癌前阶段形态学和胶原密度的改变。
The objective of this study was to evaluate the nonlinear optical microscopy techniques of multiphoton autofluorescence microscopy (MPAM) and second harmonic generation microscopy (SHGM) for noninvasive imaging of oral epithelial carcinogenesis. In vivo imaging was performed in a hamster model for oral carcinogenesis to characterize optical and morphometric alterations during neoplastic transformation. Data is presented showing alterations in morphometry and collagen density during the precancerous phase of neoplastic transformation.