Strategies to discover regulatory circuits of the mammalian immune system
Strategies to discover regulatory circuits of the mammalian immune system
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DOI：
10.1038/nri3109
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发表时间：
2011-12-01
影响因子：
100.3
通讯作者：
Hacohen, Nir
中科院分区：
文献类型：
--
作者：
Amit, Ido;Regev, Aviv;Hacohen, Nir
基因组和蛋白质组规模的测量和扰动技术的最新进展有望加速生物学和医学各个方面的发现。虽然如此快速的技术进步提供了巨大的机会，但它也要求我们学习如何有效地使用这些工具。遗传和分子网络的无偏重建是提高我们对生物系统理解的一个巨大潜力。免疫系统的细胞为开发和应用这些方法提供了特别有用的模型。在这里，我们审查的信号和转录网络的重建方法，重点是在哺乳动物先天免疫系统中的应用。
Recent advances in technologies for genome- and proteome-scale measurements and perturbations promise to accelerate discovery in every aspect of biology and medicine. Although such rapid technological progress provides a tremendous opportunity, it also demands that we learn how to use these tools effectively. One application with great potential to enhance our understanding of biological systems is the unbiased reconstruction of genetic and molecular networks. Cells of the immune system provide a particularly useful model for developing and applying such approaches. Here, we review approaches for the reconstruction of signalling and transcriptional networks, with a focus on applications in the mammalian innate immune system.