Chromosomal localization of murine and human oligodendrocyte-specific protein genes.
Chromosomal localization of murine and human oligodendrocyte-specific protein genes.
复制标题
小鼠和人类少突胶质细胞特异性蛋白基因的染色体定位。
DOI：
10.1006/geno.1996.0278
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Farber,DB
中科院分区：
文献类型：
--
作者：
Bronstein,JM;Kozak,CA;Chen,XN;Wu,S;Danciger,M;Korenberg,JR;Farber,DB
少突胶质细胞特异性蛋白（Oligodendrocyte-specific protein，OSP）是近年来发现的一种仅存在于中枢神经系统髓鞘中的蛋白质。髓鞘的几种遗传性疾病是由髓鞘基因突变引起的，但许多的病因仍然未知。我们将小鼠OSP基因的位置映射到3号染色体的近端区域，使用两组多位点杂交，并使用体细胞杂交将其映射到人类3号染色体。用荧光原位杂交技术将OSP基因定位于人染色体3q26.2-q26.3。迄今为止，还没有已知的遗传性神经系统疾病局限于这些区域。
Oligodendrocyte-specific protein (OSP) is a recently described protein present only in myelin of the central nervous system. Several inherited disorders of myelin are caused by mutations in myelin genes but the etiology of many remain unknown. We mapped the location of the mouse OSP gene to the proximal region of chromosome 3 using two sets of multilocus crosses and to human chromosome 3 using somatic cell hybrids. Fine mapping with fluorescencein situhybridization placed the OSP gene at human chromosome 3q26.2–q26.3. To date, there are no known inherited neurological disorders that localize to these regions.