Human antibody responses to avian influenza A(H7N9) virus, 2013.
Human antibody responses to avian influenza A(H7N9) virus, 2013.
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DOI：
10.3201/eid2002.131094
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发表时间：
2014-02
影响因子：
11.8
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Guo L;Zhang X;Ren L;Yu X;Chen L;Zhou H;Gao X;Teng Z;Li J;Hu J;Wu C;Xiao X;Zhu Y;Wang Q;Pang X;Jin Q;Wu F;Wang J
了解宿主抗体反应对于预测疾病严重程度和疫苗开发至关重要。我们研究了来自21名患者的48份血清样本中针对甲型H7N9流感病毒的抗体应答，其中包括来自15名患者的配对样本。在急性期样本中未检测到抗H7亚型IgG和中和抗体（NAb），但在恢复期样本中ELISA几何平均滴度增加; NAb滴度为20-80（几何平均滴度40）。对H7亚型IgG的亲和力显着低于对H1和H3亚型的亲和力。抗H3的IgG在感染甲型流感（H7N9）病毒后增强，其在急性期样品中的水平与在恢复期样品中的抗H7的水平相关。还发现血凝素抑制和NAb滴度之间以及血凝素抑制和针对H7的IgG滴度之间存在相关性。由于对甲型H7N9流感的保护性抗体反应相对较弱，可能需要多次接种疫苗才能实现保护性免疫。
Understanding host antibody response is crucial for predicting disease severity and for vaccine development. We investigated antibody responses against influenza A(H7N9) virus in 48 serum samples from 21 patients, including paired samples from 15 patients. IgG against subtype H7 and neutralizing antibodies (NAbs) were not detected in acute-phase samples, but ELISA geometric mean titers increased in convalescent-phase samples; NAb titers were 20–80 (geometric mean titer 40). Avidity to IgG against subtype H7 was significantly lower than that against H1 and H3. IgG against H3 was boosted after infection with influenza A(H7N9) virus, and its level in acute-phase samples correlated with that against H7 in convalescent-phase samples. A correlation was also found between hemagglutinin inhibition and NAb titers and between hemagglutinin inhibition and IgG titers against H7. Because of the relatively weak protective antibody response to influenza A(H7N9), multiple vaccinations might be needed to achieve protective immunity.
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人类感染新型禽源甲型流感 (H7N9) 病毒。
影响因子：
158.5
作者：
Gao, Rongbao;Cao, Bin;Shu, Yuelong
通讯作者：
Shu, Yuelong
影响因子：
11.8
作者：
Ostrowsky B;Huang A;Terry W;Anton D;Brunagel B;Traynor L;Abid S;Johnson G;Kacica M;Katz J;Edwards L;Lindstrom S;Klimov A;Uyeki TM
通讯作者：
Uyeki TM
影响因子：
11.8
作者：
Arzey GG;Kirkland PD;Arzey KE;Frost M;Maywood P;Conaty S;Hurt AC;Deng YM;Iannello P;Barr I;Dwyer DE;Ratnamohan M;McPhie K;Selleck P
通讯作者：
Selleck P
影响因子：
5.4
作者：
Jonges, Marcel;Bataille, Arnaud;Koopmans, Marion
通讯作者：
Koopmans, Marion
影响因子：
4.8
作者：
De Groot AS;Ardito M;Terry F;Levitz L;Ross T;Moise L;Martin W
通讯作者：
Martin W