Tailoring the surface properties of poly(dimethylsiloxane) microfluidic devices
Tailoring the surface properties of poly(dimethylsiloxane) microfluidic devices
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DOI：
10.1021/la049974l
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发表时间：
2004-06-22
期刊：
影响因子：
3.9
通讯作者：
Allbritton, NL
中科院分区：
文献类型：
--
作者：
Hu, SW;Ren, XQ;Allbritton, NL
聚二甲基硅氧烷（PDMS）由于其易于制造、低成本和光学透明性而成为微电泳应用的有吸引力的材料。然而，与玻璃相比，其用途仍然有限。一个主要原因是难以定制PDMS的表面性质。我们展示了共混合单体的UV接枝，以在简单的一步过程中定制PDMS微流体通道的表面特性。通过将中性单体与带电单体以不同比例共混，可以选择中性单体的性质与带电单体的性质之间的性质。四种不同的中性单体和两种不同的带电单体的混合物接枝到PDMS表面上。功能性微通道由接枝有每种不同混合物的PDMS半体制成。通过改变带电单体的浓度，可获得电泳迁移率在+4 × 10 ~（-4）cm ~（2）/（Vs）~-2 × 10 ~（-4）cm ~（2）/（Vs）之间的微通道。此外，涂层表面的接触角和涂层微通道的电泳迁移率随时间和暴露于空气时稳定。通过仔细选择具有适当性质的单体的混合物，可以针对大量不同的应用定制PDMS的表面。
Poly(dimethylsiloxane) (PDMS) is an attractive material for microelectrophoretic applications because of its ease of fabrication, low cost, and optical transparency. However, its use remains limited compared to that of glass. A major reason is the difficulty of tailoring the surface properties of PDMS. We demonstrate UV grafting of co-mixed monomers to customize the surface properties of PDMS microfluidic channels in a simple one-step process. By co-mixing a neutral monomer with a charged monomer in different ratios, properties between those of the neutral monomer and those of the charged monomer could be selected. Mixtures of four different neutral monomers and two different charged monomers were grafted onto PDMS surfaces. Functional microchannels were fabricated from PDMS halves grafted with each of the different mixtures. By varying the concentration of the charged monomer, microchannels with electrophoretic mobilities between +4 x 10(-4) cm(2)/(V s) and -2 x 10(-4) cm(2)/(V s) were attainable. In addition, both the contact angle of the coated surfaces and the electrophoretic mobility of the coated microchannels were stable over time and upon exposure to air. By carefully selecting mixtures of monomers with the appropriate properties, it may be possible to tailor the surface of PDMS for a large number of different applications.