Sevoflurane Induces Coherent Slow-Delta Oscillations in Rats.
Sevoflurane Induces Coherent Slow-Delta Oscillations in Rats.
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DOI：
10.3389/fncir.2017.00036
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发表时间：
2017
影响因子：
3.5
通讯作者：
Solt K
中科院分区：
文献类型：
--
作者：
Guidera JA;Taylor NE;Lee JT;Vlasov KY;Pei J;Stephen EP;Mayo JP;Brown EN;Solt K
尽管外科手术患者通常使用全麻来诱导意识丧失，但麻醉引起的无意识的机制尚不完全清楚。在大鼠中，我们描述了硬膜外脑电图和前额皮质（PFC）、顶叶皮质（PC）和中央丘脑（CT）内的颅内局部场电位（LFPs）对逐渐增加剂量的吸入麻醉剂七氟醚的反应。在低剂量七氟醚诱导下，额叶脑电图和PFC、PC和CT LFP的β /低伽马（12-40 Hz）功率增加，PFC - CT和PFC - PFC LFP的β /低伽马相干性增加。运动丧失（LOM）与β /低γ PFC-CT LFP相干性的突然下降同时发生。LOM后，在额叶脑电图和PFC、PC和CT lfp中观察到皮层相干慢δ (0.1-4 Hz)振荡。在高剂量的七氟醚足以导致翻正反射丧失时，在额叶脑电图和PFC、PC和CT LFPs中，连贯的慢δ振荡占主导地位。在动物从七氟醚麻醉中苏醒时，观察到与诱导过程相似的动力学。我们得出结论，大鼠是七氟醚诱导的人类脑电图振荡的有用动物模型，并且连贯的慢δ振荡与七氟醚诱导的大鼠行为停止和失直相关。
Although general anesthetics are routinely administered to surgical patients to induce loss of consciousness, the mechanisms underlying anesthetic-induced unconsciousness are not fully understood. In rats, we characterized changes in the extradural EEG and intracranial local field potentials (LFPs) within the prefrontal cortex (PFC), parietal cortex (PC), and central thalamus (CT) in response to progressively higher doses of the inhaled anesthetic sevoflurane. During induction with a low dose of sevoflurane, beta/low gamma (12–40 Hz) power increased in the frontal EEG and PFC, PC and CT LFPs, and PFC–CT and PFC–PFC LFP beta/low gamma coherence increased. Loss of movement (LOM) coincided with an abrupt decrease in beta/low gamma PFC–CT LFP coherence. Following LOM, cortically coherent slow-delta (0.1–4 Hz) oscillations were observed in the frontal EEG and PFC, PC and CT LFPs. At higher doses of sevoflurane sufficient to induce loss of the righting reflex, coherent slow-delta oscillations were dominant in the frontal EEG and PFC, PC and CT LFPs. Dynamics similar to those observed during induction were observed as animals emerged from sevoflurane anesthesia. We conclude that the rat is a useful animal model for sevoflurane-induced EEG oscillations in humans, and that coherent slow-delta oscillations are a correlate of sevoflurane-induced behavioral arrest and loss of righting in rats.