Phosphorothioation of DNA in bacteria by dnd genes
Phosphorothioation of DNA in bacteria by dnd genes
复制标题
dnd 基因对细菌中 DNA 进行硫代磷酸化
DOI：
10.1038/nchembio.2007.39
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发表时间：
2007-11-01
影响因子：
14.8
通讯作者：
Dedon, Peter C.
中科院分区：
文献类型：
--
作者：
Wang, Lianrong;Chen, Shi;Dedon, Peter C.
DNA和RNA的典型结构的修饰在所有生物体中的细胞生理学、DNA复制、转录和翻译中起关键作用。我们现在报告细菌dnd基因簇将硫作为序列选择性的立体特异性硫代磷酸酯修饰纳入DNA骨架。据我们所知，与任何其他DNA或RNA修饰系统不同，通过dnd基因簇进行的DNA硫代磷酸化是在DNA骨架上描述的第一种生理修饰。
Modifications of the canonical structures of DNA and RNA play critical roles in cell physiology, DNA replication, transcription and translation in all organisms. We now report that bacterial dnd gene clusters incorporate sulfur into the DNA backbone as a sequence-selective, stereospecific phosphorothioate modification. To our knowledge, unlike any other DNA or RNA modification systems, DNA phosphorothioation by dnd gene clusters is the first physiological modification described on the DNA backbone.