Role of NOD1/CARD4 and NOD2/CARD15 gene polymorphisms in cancer etiology
Role of NOD1/CARD4 and NOD2/CARD15 gene polymorphisms in cancer etiology
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DOI：
10.1016/j.humimm.2011.06.003
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发表时间：
2011-10-01
期刊：
影响因子：
2.7
通讯作者：
Kutikhin, Anton G.
中科院分区：
文献类型：
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作者：
Kutikhin, Anton G.
NOD 1/CARD 4和NOD 2/CARD 15是Nod样受体家族的成员。它们位于细胞溶质中，结合细菌和病毒配体，并在实现先天性和适应性免疫应答、细胞凋亡、自噬和活性氧产生中发挥关键作用。NOD1/CARD4和NOD2/CARD15基因的多态性可能会改变促炎细胞因子和抗炎细胞因子之间的平衡，从而调节感染、慢性炎症和癌症的风险。NOD1/CARD4和NOD2/CARD15基因多态性可能与胃癌、结直肠癌、乳腺癌、卵巢癌、前列腺癌、睾丸癌、肺癌、喉癌、肝癌、胆囊癌、胆道癌、胰腺癌、小肠癌、肾癌、膀胱癌、皮肤癌、非甲状腺内分泌肿瘤、淋巴瘤和白血病的风险改变相关。用于癌基因组研究的这种多态性前景的短列表可以包括rs2006847、rs2066845、rs2066844、rs2066842、ND（1）+32656、rs2075820，而rs104895493、rs104895476、rs104895475、rs104895474、rs104895473、rs104895476、rs104895475、rs104895474、rs104895473、rs104895476、rs104895475、rs104895474、rs104895473、rs104895476、rs104 rs104895472、rs104895462、rs104895461、rs104895460、rs104895438、rs5743291、rs5743260、rs2076756、rs2066843、Pro371Thr、Ala794Pro、Gln908His、rs72551113、rs72551107、rs6958571、可以将RS2907749、RS2907748、RS2075822、RS2075819、RS2075818添加到扩展列表。不同研究之间差异的原因包括混杂宿主遗传、细菌或环境因素，这些因素调节变异等位基因的突变率并影响增加癌症风险的病症的风险，不同细菌对此类病症的病因学的影响，样本量、临床病理学特征、诊断、分层、基因分型方法和机会的差异。(C)2011年美国组织相容性和免疫遗传学学会。爱思唯尔公司出版All rights reserved.
NOD1/CARD4 and NOD2/CARD15 are members of Nod-like receptor family. They are located in cytosol, bind bacterial and viral ligands and play a key role in realization of innate and adaptive immune response, apoptosis, autophagy, and reactive oxygen species generation. Polymorphisms in NOD1/CARD4 and NOD2/CARD15 genes may shift balance between pro- and anti-inflammatory cytokines, modulating the risk of infection, chronic inflammation and cancer. NOD1/CARD4 and NOD2/CARD15 gene polymorphisms may be associated with altered risk of gastric, colorectal, breast, ovarian, prostate, testicular, lung, laryngeal, liver, gallbladder, biliary tract, pancreatic, small bowel, kidney, urinary bladder cancer, skin cancer, nonthyroid endocrine tumors, lymphoma and leukemia. The short list of such polymorphisms perspective for oncogenomic investigations may include rs2006847, rs2066845, rs2066844, rs2066842, ND(1)+32656, rs2075820 whereas rs104895493, rs104895476, rs104895475, rs104895474, rs104895473, rs104895472, rs104895462, rs104895461, rs104895460, rs104895438, rs5743291, rs5743260, rs2076756, rs2066843, Pro371Thr, Ala794Pro, Gln908His, rs72551113, rs72551107, rs6958571, rs2907749, rs2907748, rs2075822, rs2075819, rs2075818 may be added to the extended list. Reasons of discrepancies between different studies include confounding host genetic, bacterial, or environmental factors modulating penetrance of variant allele and affecting risk of condition increasing cancer risk, different bacterial impact in aetiology of such conditions, differences in sample size, clinicopathological characteristics, diagnostics, stratification, genotyping methods, and chance. (C) 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.