Spatial distribution and registry-based case-control analysis of Campylobacter infections in Denmark, 1991-2001
Spatial distribution and registry-based case-control analysis of Campylobacter infections in Denmark, 1991-2001
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DOI：
10.1093/aje/kwi316
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发表时间：
2005-11-15
影响因子：
5
通讯作者：
Molbak, K
中科院分区：
文献类型：
--
作者：
Ethelberg, S;Simonsen, J;Molbak, K
使用11年(1991-2001)期间的数据，作者分析了丹麦所有登记的、实验室确认的、国内获得的弯曲杆菌病病例的居住地点信息。患者数据与国家住房和地址登记簿中的数据合并，并使用丹麦人口登记簿构建人口密度指数。这项研究是以登记为基础的病例对照研究；从国家人口登记中为每个病例选择15名年龄匹配的对照。在Logistic回归分析中，共有22,066例患者与318,958名对照组进行了比较。居住在农村地区的住房类型和居住在人口密度低的地区都与感染风险增加有关。这种关系特别与儿童有关，解释了农村儿童中三分之一的病例。此外，在一些县，感染与提供家庭服务的饮用水公司的类型之间存在关联。这项研究表明，在丹麦农村，与动物或环境的接触是相当大比例的零星弯曲杆菌感染的来源，特别是在儿童中。
Using data from an 11-year period (1991-2001), the authors analyzed available information on location of residence for all registered, laboratory-confirmed, domestically acquired cases of campylobacteriosis in Denmark. Patient data were merged with data from a national register on housing and addresses, and a population density index was constructed using the Danish population register. The study was performed as a register-based case-control study; 15 age-matched controls for each case were selected from the national population register. A total of 22,066 cases were compared with 318,958 controls in logistic regression analysis. Living in types of housing found in rural areas and living in areas with a low population density were both associated with an increased risk of infection. This relation concerned children in particular and explained one third of cases among children in the countryside. Furthermore, in some counties there was an association between infection and type of drinking-water company serving the home. This study indicated that contact with animals or the environment is the source of a substantial proportion of sporadic Campylobacter infections in the Danish countryside, particularly among children.