The safety assessment of fragrance materials
The safety assessment of fragrance materials
复制标题
DOI：
10.1016/s0273-2300(03)00003-5
复制
发表时间：
2003-04-01
影响因子：
3.4
通讯作者：
Tagami, H
中科院分区：
文献类型：
--
作者：
Bickers, DR;Calow, P;Tagami, H
对用作香料成分的大量不同化学品的安全性评估遵循系统的数据生成和分析优先级，考虑暴露和对可用信息质量的关键分析。在先前的出版物中，综述了香料研究所（RIFM）的研究重点和工业使用的暴露估计方法。本文提供了RIFM专家小组（REXPAN）使用的方法的详细信息，以检查使用和暴露于香味材料的皮肤影响，系统毒性和环境后果，从而可以在预期条件下可靠地确定安全使用。这种分析的有用性的关键在于根据化学结构将2600多种分立的成分分组。RIFM赞助的研究、成员公司提供的数据以及来自许多来源的相关出版报告都是在危险表征过程中考虑的因素。讨论了REXPAN的决策树方法来评估皮肤、系统和环境端点，以及所包含数据的类型和质量。整个过程的结果是提供给国际香料协会（IFRA）作为考虑新的或现有香料材料标准的基础，并为行业提供适当的产品风险管理行动。(C) 2003 Elsevier Science（美国）版权所有。
Safety evaluation of the large number of diverse chemicals used as fragrance ingredients follows a systematic prioritization of data generation and analysis, consideration of exposure and critical analysis of the quality of the available information. In prior publications the research priorities used by the Research Institute for Fragrance Materials (RIFM), and the methods of exposure estimation used by industry have been summarized. This paper provides details of the approach used by the RIFM Expert Panel (REXPAN), to examine the dermal effects, systemic toxicity and environmental consequences of the use of and exposure to fragrance materials, which allow a reliable determination of safe use under intended conditions. The key to the usefulness of this analysis is the grouping of more than 2600 discrete ingredients into classes, based on chemical structures. Research sponsored by RIFM, data supplied by member companies, and relevant published reports from many sources are all considered during hazard characterization. A discussion is provided of REXPAN's decision tree approach to assessing the dermal, systemic and environmental endpoints and the types and quality of data included. This overall process results in well-documented conclusions which are provided to the International Fragrance Association (IFRA) as the basis for consideration of a new or existing Fragrance Material Standard and to industry for appropriate product risk management actions. (C) 2003 Elsevier Science (USA). All rights reserved.