Tissue‐Adaptive Materials with Independently Regulated Modulus and Transition Temperature
Tissue‐Adaptive Materials with Independently Regulated Modulus and Transition Temperature
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DOI：
10.1002/adma.202005314
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发表时间：
2020-11
影响因子：
29.4
通讯作者：
Daixuan Zhang;E. Dashtimoghadam;F. Fahimipour;Xiaobo Hu;Qiaoxi Li;Egor A Bersenev;D. Ivanov;Mohammad Vatankhah‐Varnoosfaderani;S. Sheiko
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文献类型：
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作者：
Daixuan Zhang;E. Dashtimoghadam;F. Fahimipour;Xiaobo Hu;Qiaoxi Li;Egor A Bersenev;D. Ivanov;Mohammad Vatankhah‐Varnoosfaderani;S. Sheiko
生物物种在刚性和柔性形状之间转换的能力代表了它们的生存机制之一，这已被各种人类技术所采用。这种过渡在医疗装置中是特别期望的，因为刚性有利于植入过程，而柔性和柔软性有利于与周围组织的生物相容性。传统的热塑性塑料无法与软组织力学相匹配，而凝胶会渗入人体并随着时间的推移改变其特性。在这里，演示了一个单组分系统，在28-43 °C的受控温度下，杨氏模量从GPa到kPa水平前所未有地下降了多达六个数量级。这种方法基于具有可结晶侧链的刷状聚合物网络，例如，聚（戊内酯），通过同时改变侧链长度和交联密度来提供熔融温度和杨氏模量的独立控制。在生理温度下软化至组织水平允许设计组织适应性植入物，其可以作为刚性器械插入，然后在体温下匹配周围组织力学。这种转变还使得嵌入药物的热触发释放能够用于抗炎治疗。
The ability of living species to transition between rigid and flexible shapes represents one of their survival mechanisms, which has been adopted by various human technologies. Such transition is especially desired in medical devices as rigidity facilitates the implantation process, while flexibility and softness favor biocompatibility with surrounding tissue. Traditional thermoplastics cannot match soft tissue mechanics, while gels leach into the body and alter their properties over time. Here, a single‐component system with an unprecedented drop of Young's modulus by up to six orders of magnitude from the GPa to kPa level at a controlled temperature within 28–43 °C is demonstrated. This approach is based on brush‐like polymer networks with crystallizable side chains, e.g., poly(valerolactone), affording independent control of melting temperature and Young's modulus by concurrently altering side chain length and crosslink density. Softening down to the tissue level at the physiological temperature allows the design of tissue‐adaptive implants that can be inserted as rigid devices followed by matching the surrounding tissue mechanics at body temperature. This transition also enables thermally triggered release of embedded drugs for anti‐inflammatory treatment.