Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis
Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis
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DOI：
10.1016/s0962-8924(98)01382-8
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发表时间：
1999-01-01
影响因子：
19
通讯作者：
Thomas, G
中科院分区：
文献类型：
--
作者：
Molloy, SS;Anderson, ED;Thomas, G
Furin是一种分泌途径内蛋白酶，在反式高尔基体网络(TGN)/内体系统的多个区室中，催化从生长因子和受体到病原体蛋白的多种蛋白底物的成熟。本文综述了内源性蛋白酶在生物化学和细胞生物学方面的最新进展，包括TGN定位的机制、磷酸化依赖的蛋白质运输调节，以及对早期胚胎发生、细胞外基质形成和病原体毒力的新见解。
Furin is a secretory Pathway endoprotease that catalyses the maturation of a strikingly diverse group of proprotein substrates, ranging from growth factors and receptors to pathogen proteins, In multiple compartments within the trans-Golgi network (TGN)/endosomal system. This review focuses on recent developments in the biochemistry and cell biology of the endoprotease, including the mechanism of TGN localization, phosphorylation-dependent regulation of protein traffic, and novel insights into, early embryogenesis, extracellular matrix formation and pathogen virulence.