Individual differences in the morphometry and activation of time perception networks are influenced by dopamine genotype.
Individual differences in the morphometry and activation of time perception networks are influenced by dopamine genotype.
复制标题
形态测量和时间感知网络激活的个体差异受到多巴胺基因型的影响。
DOI：
10.1016/j.neuroimage.2013.11.019
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发表时间：
2014
期刊：
影响因子：
5.7
通讯作者：
Coslett,HBranch
中科院分区：
文献类型：
--
作者：
Wiener,Martin;Lee,Yune-Sang;Lohoff,FalkW;Coslett,HBranch
个体参与者估计和区分时间间隔的能力差异很大。这种表现的异质性可能是由于对不同时间感知网络的依赖以及这些网络内用于计时的大脑结构的激活的个体差异造成的。为了解决这些可能性，我们利用了事件相关的功能磁共振成像 (fMRI)，同时人类参与者 (n = 25) 执行了时间或颜色辨别任务。此外，根据我们之前的研究，我们对参与者进行了 DRD2/ANKK1-Taq1a 基因分型，这是一种单核苷酸多态性，与纹状体 D2 密度降低 30-40% 相关，并与较差的计时表现相关。与之前的报告类似，我们的样本中发现了各种各样的性能；至关重要的是，与颜色任务相比，计时任务的更好表现与先前与计时相关的前额叶和皮层下区域的更大激活有关。此外，基于体素的形态测量表明，更好的计时性能还与右侧小脑体积的增加相关。我们的分析还显示，Taq1a 多态性的 A1 携带者在时间辨别方面表现相对较差，但在颜色辨别方面表现不佳，但纹状体和右背外侧前额叶皮层的激活程度较高，并且小脑簇的体积减小。这些结果指出了人类异质计时表现的神经基础，并表明时间辨别任务的表现差异部分归因于 DRD2/ANKK1 基因型。
Individual participants vary greatly in their ability to estimate and discriminate intervals of time. This heterogeneity of performance may be caused by reliance on different time perception networks as well as individual differences in the activation of brain structures utilized for timing within those networks. To address these possibilities we utilized event-related functional magnetic resonance imaging (fMRI) while human participants (n = 25) performed a temporal or color discrimination task. Additionally, based on our previous research, we genotyped participants for DRD2/ANKK1-Taq1a, a single-nucleotide polymorphism associated with a 30–40% reduction in striatal D2 density and associated with poorer timing performance. Similar to previous reports, a wide range of performance was found across our sample; crucially, better performance on the timing versus color task was associated with greater activation in prefrontal and sub-cortical regions previously associated with timing. Furthermore, better timing performance also correlated with increased volume of the right lateral cerebellum, as demonstrated by voxel-based morphometry. Our analysis also revealed that A1 carriers of the Taq1a polymorphism exhibited relatively worse performance on temporal, but not color discrimination, but greater activation in the striatum and right dorsolateral prefrontal cortex, as well as reduced volume in the cerebellar cluster. These results point to the neural bases for heterogeneous timing performance in humans, and suggest that differences in performance on a temporal discrimination task are, in part, attributable to the DRD2/ANKK1 genotype.