Tissue-specific and plasma microRNA profiles could be promising biomarkers of histological classification and TNM stage in non-small cell lung cancer.
Tissue-specific and plasma microRNA profiles could be promising biomarkers of histological classification and TNM stage in non-small cell lung cancer.
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DOI：
10.1111/1759-7714.12317
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发表时间：
2016-04-26
期刊：
影响因子：
2.9
通讯作者：
Dai Y
中科院分区：
文献类型：
--
作者：
Pu Q;Huang Y;Lu Y;Peng Y;Zhang J;Feng G;Wang C;Liu L;Dai Y
在先前的研究中，我们确定血浆miRNA是吸烟相关肺纤维化的潜在生物标志物。在此，我们确定组织特异性和血浆miRNA谱是否可以成为非小细胞肺癌（NSCLC）组织学分类和TNM分期的有希望的生物标志物。在NSCLC患者和匹配的健康对照中进行术前和术后7天的血浆miRNA分析，以及癌症和正常组织miRNA分析。在NSCLC患者和对照之间，所有特征miRNA都有>两倍的变化，P值< 0.05。我们发现，组织特异性和血浆miR-211 - 3 p、miR-3679 - 3 p和miR-4787 - 5 p是不同分期肺鳞状细胞癌有希望的生物标志物，而miR-3613 - 3 p、miR-3675 - 3 p和miR-5571 - 5 p是不同分期肺腺癌有希望的生物标志物。这些结果表明，组织特异性和血浆miRNA可能是NSCLC组织学分类和TNM分期的潜在生物标志物。
In a previous study, we determined that plasma miRNAs are potential biomarkers for cigarette smoking‐related lung fibrosis. Herein, we determine whether tissue‐specific and plasma miRNA profiles could be promising biomarkers for histological classification and TNM stage in non‐small cell lung cancer (NSCLC). Plasma miRNA profiling preoperatively and seven days postoperatively, and cancer and normal tissue miRNA profiling were performed in NSCLC patients and matched healthy controls. There was a > twofold change for all signature miRNAs between the NSCLC patients and controls, with P values of < 0.05. We found that tissue‐specific and plasma miR‐211‐3p, miR‐3679‐3p, and miR‐4787‐5p were promising biomarkers of different staging lung squamous cell carcinoma, and miR‐3613‐3p, miR‐3675‐3p, and miR‐5571‐5p were promising biomarkers of different staging lung adenocarcinoma. These results suggest that tissue‐specific and plasma miRNAs could be potential biomarkers of histological classification and TNM stage in NSCLC.