Relation of high cytomegalovirus antibody titres to blood pressure and brachial artery flow-mediated dilation in young men: the Cardiovascular Risk in Young Finns Study
Relation of high cytomegalovirus antibody titres to blood pressure and brachial artery flow-mediated dilation in young men: the Cardiovascular Risk in Young Finns Study
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DOI：
10.1111/j.1365-2249.2011.04513.x
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发表时间：
2012-02-01
影响因子：
4.6
通讯作者：
Hurme, M.
中科院分区：
文献类型：
--
作者：
Haarala, A.;Kahonen, M.;Hurme, M.
在免疫功能低下的器官移植患者中，人巨细胞病毒(CMV)感染与心血管疾病的风险增加相关。它与动脉血压升高的发病机制有关。然而，关于CMV感染是否与内皮功能有关还存在争议，而且对于其作为早期动脉粥样硬化发生的潜在危险因素的作用也知之甚少。我们的目的是发现CMV抗体滴度是否与早期血管变化(颈动脉内膜中层厚度、颈动脉扩张性和肱动脉血流介导的扩张)、血压升高或其他传统心血管危险因素有关。对参加芬兰青年心血管风险研究的1074名女性和857名男性(年龄24-39岁)进行了CMV抗体滴度测定。女性的CMV抗体滴度明显高于男性。在男性中，巨细胞病毒抗体滴度与年龄(P<；0.001)、收缩压(P=0.053)和舒张压(P=0.002)升高直接相关，与血流介导的扩张呈负相关(P=0.014)。在女性中，CMV抗体滴度与任何分析参数都没有关联。在包含传统动脉粥样硬化危险因素的多元回归模型中，巨细胞病毒抗体滴度是男性收缩压(P=0.029)和舒张压(P=0.004)升高和血流介导的扩张(P=0.014)的独立决定因素。在年轻男性中，高CMV抗体滴度与血压和肱动脉血流介导的扩张独立相关。这种关联支持一种假设，即常见的CMV感染和/或对CMV的免疫反应可能会在年轻时导致血管功能受损。
Human cytomegalovirus (CMV) infection is associated with a higher risk of cardiovascular disease in immunocompromised organ transplant patients. It has been linked with the pathogenesis of elevated arterial blood pressure. However, controversy exists as to whether CMV infection is associated with endothelial function, and little is known about its role as a potential risk factor for early atherosclerosis development at a young age. We aimed to discover if CMV antibody titres are associated with early vascular changes (carotid intima-media thickness, carotid artery distensibility and brachial artery flow-mediated dilation), blood pressure elevation or other traditional cardiovascular risk factors. CMV antibody titres were measured in 1074 women and 857 men (aged 24-39 years) taking part in the Cardiovascular Risk in Young Finns study. CMV antibody titres were significantly higher in women compared to men. In men, high CMV antibody titres were associated directly with age (P < 0.001) and systolic (P = 0.053) and diastolic (P = 0.002) blood pressure elevation, and associated inversely with flow-mediated dilation (P = 0.014). In women, CMV antibody titres did not associate with any of the analysed parameters. In a multivariate regression model, which included traditional atherosclerotic risk factors, CMV antibody titres were independent determinants for systolic (P = 0.029) and diastolic (P = 0.004) blood pressure elevation and flow-mediated dilation (P = 0.014) in men. High CMV antibody titres are associated independently with blood pressure and brachial artery flow-mediated dilation in young men. This association supports the hypothesis that common CMV infection and/or an immune response to CMV may lead to impaired vascular function at a young age.