Meditation experience predicts less negative appraisal of pain: Electrophysiological evidence for the involvement of anticipatory neural responses
Meditation experience predicts less negative appraisal of pain: Electrophysiological evidence for the involvement of anticipatory neural responses
复制标题
DOI：
10.1016/j.pain.2010.04.017
复制
发表时间：
2010-09-01
期刊：
影响因子：
7.4
通讯作者：
Jones, Anthony K. P.
中科院分区：
文献类型：
--
作者：
Brown, Christopher A.;Jones, Anthony K. P.
正念冥想的目的是培养专注于当下的、非评判性的注意力。因此，冥想的经验应该与较少的预期和对疼痛的负面评价有关。在这项研究中，我们比较了一组有冥想经验的人与对照组，以测试是否有任何差异的情感评估疼痛可以解释较低的预期神经处理。预期和疼痛诱发的ERP和报告的疼痛不愉快的记录在两组之间匹配的主观强度的激光刺激。ERP数据经LORETA源估计后进行分析。在用于诱发疼痛的激光能量上未发现组效应。相对于对照组，更有经验的冥想者感觉到的疼痛不那么令人不快，冥想体验与不快评级呈负相关。预期的ERP源数据显示，在冥想者中，中扣带回皮层相对于对照组的较低活动与较低的不愉快评级有关，并且可以通过终身冥想经验进行预测。冥想者还逆转了内侧前额叶皮层活动与预期期间疼痛不愉快之间的正常正相关性。在疼痛诱发反应期间，冥想也与52和54的活动降低有关，尽管实验无法将这种活动与先前的预期反应区分开来。我们的数据是一致的假设，即冥想减少了预期和负面评价的疼痛，但对疼痛诱发的活动的影响不太清楚，可能源于先前的预期活动。需要进一步的工作来直接测试冥想，疼痛预期和疼痛体验之间的因果关系。(C)2010年国际疼痛研究协会。Elsevier B.V.出版，保留所有权利。
The aim of mindfulness meditation is to develop present-focused, non-judgmental, attention. Therefore, experience in meditation should be associated with less anticipation and negative appraisal of pain. In this study we compared a group of individuals with meditation experience to a control group to test whether any differences in the affective appraisal of pain could be explained by lower anticipatory neural processing. Anticipatory and pain-evoked ERPs and reported pain unpleasantness were recorded in response to laser stimuli of matched subjective intensity between the two groups. ERP data were analysed after source estimation with LORETA. No group effects were found on the laser energies used to induce pain. More experienced meditators perceived the pain as less unpleasant relative to controls, with meditation experience correlating inversely with unpleasantness ratings. ERP source data for anticipation showed that in meditators, lower activity in midcingulate cortex relative to controls was related to the lower unpleasantness ratings, and was predicted by lifetime meditation experience. Meditators also reversed the normal positive correlation between medial prefrontal cortical activity and pain unpleasantness during anticipation. Meditation was also associated with lower activity in 52 and insula during the pain-evoked response, although the experiment could not disambiguate this activity from the preceding anticipation response. Our data is consistent with the hypothesis that meditation reduces the anticipation and negative appraisal of pain, but effects on pain-evoked activity are less clear and may originate from preceding anticipatory activity. Further work is required to directly test the causal relationship between meditation, pain anticipation, and pain experience. (C) 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.