m Exploration of inclusion complexes of neurotransmitters with β-cyclodextrin by physicochemical techniques
m Exploration of inclusion complexes of neurotransmitters with β-cyclodextrin by physicochemical techniques
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DOI：
10.1016/j.cplett.2016.05.031
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发表时间：
2016-07-01
影响因子：
2.8
通讯作者：
Barman, Siti
中科院分区：
文献类型：
--
作者：
Roy, Mahendra Nath;Saha, Subhadeep;Barman, Siti
β-环糊精与几种最重要的神经递质（即盐酸多巴胺、盐酸酪胺和（+/-）-盐酸肾上腺素）在水介质中的分子组装体已通过可靠的光谱和物理化学技术作为潜在的药物递送系统进行了探索。作业图证实了 1:1 主客体包合络合物，而表面张力和电导率研究则说明了包合过程。通过H-1 NMR光谱对包合物进行了表征，并使用Benesi-Hildebrand方法计算了缔合常数。通过van't Hoff方程推导了包合物形成的热力学参数，这表明整个包合过程在热力学上是有利的。 (C) 2016 Elsevier B.V. 保留所有权利。
Molecular assemblies of beta-cyclodextrin with few of the most important neurotransmitters, viz., dopamine hydrochloride, tyramine hydrochloride and (+/-)-epinephrine hydrochloride in aqueous medium have been explored by reliable spectroscopic and physicochemical techniques as potential drug delivery systems. Job plots confirm the 1:1 host-guest inclusion complexes, while surface tension and conductivity studies illustrate the inclusion process. The inclusion complexes were characterized by H-1 NMR spectroscopy and association constants have been calculated by using Benesi-Hildebrand method. Thermodynamic parameters for the formation of inclusion complexes have been derived by van't Hoff equation, which demonstrate that the overall inclusion processes are thermodynamically favorable. (C) 2016 Elsevier B.V. All rights reserved.