Chemokine receptor signaling and HIV infection.
Chemokine receptor signaling and HIV infection.
复制标题
趋化因子受体信号传导和 HIV 感染。
DOI：
10.1007/978-1-60761-198-1_21
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Wu,Yuntao
中科院分区：
文献类型：
--
作者：
Wu,Yuntao
HIV-1与其趋化因子辅助受体结合的主要功能是介导融合和病毒进入。然而，已经知道这种相互作用也触发各种信号级联。病毒介导的信号传导事件可能在需要引发细胞条件的各种环境中促进病毒感染。这已经在我们最近的研究结果中举例说明，HIV-1利用case-CXCR 4相互作用来激活细胞肌动蛋白解聚因子cofilin，以支持静息CD 4 T细胞的病毒潜伏感染。cofilin的激活促进皮质肌动蛋白动力学，这对于病毒在静息T细胞中穿过静态皮质肌动蛋白屏障的细胞内迁移是至关重要的。
The primary function of HIV-1 binding to its chemokine coreceptors is to mediate fusion and viral entry. However, it has been known that this interaction also triggers a variety of signaling cascades. It is likely that the virus-mediated signaling events may facilitate viral infection in various settings where the cellular conditions need to be primed. This has been exemplified recently in our findings that HIV-1 employs envelope-CXCR4 interaction to activate a cellular actin depolymerization factor, cofilin, to support viral latent infection of resting CD4 T cells. Activation of cofilin promotes the cortical actin dynamics that are critical for viral intracellular migration across the static cortical actin barrier in resting T cells.