The slippery slope: lubricant use and rectal sexually transmitted infections: a newly identified risk.
The slippery slope: lubricant use and rectal sexually transmitted infections: a newly identified risk.
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DOI：
10.1097/olq.0b013e318235502b
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发表时间：
2012-01
影响因子：
3.1
通讯作者：
Cranston RD
中科院分区：
文献类型：
--
作者：
Gorbach PM;Weiss RE;Fuchs E;Jeffries RA;Hezerah M;Brown S;Voskanian A;Robbie E;Anton P;Cranston RD
在接受性肛交 (RAI) 期间使用润滑剂产品极为常见，但尚未被评估为感染性传播感染 (STI) 的风险。 2006 年至 2008 年，作为加州大学洛杉矶分校杀菌剂开发计划 (NIAID IPCP# #0606414) 的一部分，在巴尔的摩和洛杉矶进行了一项直肠健康和行为研究。参与者完成了问卷调查，并使用 Aptima Combo 2 检测对直肠拭子进行了淋病奈瑟菌和沙眼衣原体检测，并对血液进行了梅毒（RPR 和 TPHA 滴度）和 HIV 检测。在报告润滑剂使用情况和 RAI、STI 结果的参与者中，有 380 名参与者可获得。单变量和多变量回归评估了过去一个月 RAI 期间润滑剂使用与流行性传播感染之间的关联。 36% (137/380) 的参与者表示，过去一个月 RAI 期间一直使用润滑剂。过去一个月一致使用润滑剂的人比不一致的使用者有更高的性传播感染患病率（9.5% vs. 2.9%；p=0.006）。在多变量逻辑回归模型中，STI 检测呈阳性与过去一个月 RAI 期间持续使用润滑剂相关（在控制了过去一个月的年龄、性别、研究地点、HIV 状况和 RAI 伴侣数量后，调整优势比 (AOR) 2.98 (95%CI 1.09, 8.15)。研究结果表明，某些润滑剂产品可能会增加对 STI 的脆弱性。由于润滑剂的广泛使用及其作为杀菌剂载体的潜力，进一步研究对于澄清润滑剂的使用是否构成公共健康风险至关重要。
Use of lubricant products is extremely common during receptive anal intercourse (RAI) yet has not been assessed as a risk for acquisition of sexually transmitted infections (STIs). From 2006–2008 a rectal health and behavior study was conducted in Baltimore and Los Angeles as part of the UCLA Microbicide Development Program (NIAID IPCP# #0606414). Participants completed questionnaires and rectal swabs were tested for Neisseria gonorrhoeae and Chlamydia trachomatis with the Aptima Combo 2 assay and blood was tested for syphilis (for RPR and TPHA with titer) and HIV. Of those reporting lubricant use and RAI, STI results were available for 380 participants. Univariate and multivariate regressions assessed associations of lubricant use in the past month during RAI with prevalent STIs. Consistent lubricant use during RAI in the past month was reported by 36% (137/380) of participants. Consistent past month lubricant users had a higher prevalence of STI than inconsistent users (9.5% vs. 2.9%; p=0.006). In a multivariable logistic regression model testing positive for STI was associated with consistent use of lubricant during RAI in the past month (adjusted Odds Ratio (AOR) 2.98 (95%CI 1.09, 8.15) after controlling for age, gender, study location, HIV status, and numbers of RAI partners in the past month. Findings suggest some lubricant products may increase vulnerability to STIs. Because of wide use of lubricants and their potential as carrier vehicles for microbicides, further research is essential to clarify if lubricant use poses a public health risk.