Pre-exposure of rats to amphetamine sensitizes self-administration of this drug under a progressive ratio schedule
Pre-exposure of rats to amphetamine sensitizes self-administration of this drug under a progressive ratio schedule
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DOI：
10.1007/s002130050530
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发表时间：
1998-02-01
影响因子：
3.4
通讯作者：
Phillips, AG
中科院分区：
文献类型：
--
作者：
Mendrek, A;Blaha, CD;Phillips, AG
对两组雄性大鼠进行测试，以确定预先暴露于顺式苯丙胺是否会增强在渐进比例强化方案下自我给药的动机。在实验的第一阶段，一组大鼠接受d-苯丙胺（2 mg/kg IF），而第二组大鼠隔日接受生理盐水，共注射10次。在21天的停药期后，在d-苯丙胺预处理组中，苯丙胺诱导的刻板行为显著增加，证实了行为敏化。相对于盐水预处理组。在研究的第二阶段，所有大鼠均植入慢性颈静脉导管，并训练其在固定比例强化方案下自我给予d-苯丙胺（每次输注0.2 mg/kg）。连续7天的渐进比例范式，d-苯丙胺预处理的大鼠达到显着高于生理盐水预处理的动物的断点。这些数据表明，预先暴露于氯-苯丙胺可能会增强自我管理这种药物的动机。
Two groups of male rats were tested to determine whether pre-exposure to ci-amphetamine would enhance the motivation to self-administer the drug under a progressive ratio schedule of reinforcement. In the first phase of the experiment, one group of rats received d-amphetamine (2 mg/kg IF), while a second group received saline on alternate days for a total of ten injections, Following a 21-day drug withdrawal period, behavioral sensitization was confirmed by a significant increase in amphetamine-induced stereotypy in the d-amphetamine-pretreated group. relative to the saline-pretreated group. In thr second phase of the study, all rats were implanted with chronic jugular catheters and trained to self-administer d-amphetamine (0.2 mg/kg per infusion) under a fixed-ratio schedule of reinforcement. The progressive ratio paradigm was then imposed for 7 consecutive days, d-amphetamine-pretreated rats attained significantly higher break points than saline-pretreated animals. These data suggest that pre-exposure to cl-amphetamine may enhance the motivation to self-administer this drug.