IMMOBILITY INDUCED BY FORCED SWIMMING IN RATS - EFFECTS OF AGENTS WHICH MODIFY CENTRAL CATECHOLAMINE AND SEROTONIN ACTIVITY
IMMOBILITY INDUCED BY FORCED SWIMMING IN RATS - EFFECTS OF AGENTS WHICH MODIFY CENTRAL CATECHOLAMINE AND SEROTONIN ACTIVITY
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DOI：
10.1016/0014-2999(79)90366-2
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发表时间：
1979-01-01
影响因子：
5
通讯作者：
JALFRE, M
中科院分区：
文献类型：
--
作者：
PORSOLT, RD;BERTIN, A;JALFRE, M
被迫在受限空间游泳的大鼠将迅速停止明显的逃跑尝试，并采取一种被称为不动的特有姿势。显然，多种抗抑郁剂可以降低患者的不能动度，该方法可能可作为抗抑郁剂的筛选模型。在目前的实验中，增加中枢多巴胺能和α-肾上腺素能活性的药物减少了不动，但主要作用于中枢5-羟色胺的药物对不动影响较小。降低中枢儿茶酚胺活性的药物可以增加不动，但抑制中枢性5-羟色胺的药物则不能。显然，固定主要取决于中枢儿茶酚胺的活性，但在将固定完全归因于单个系统内的活动之前，需要谨慎。
Rats forced to swim in a restricted space will rapidly cease apparent attempts to escape and adopt a characteristic posture which was termed immobility. Apparently immobility was reduced by a variety of antidepressant agents, and the method could probably serve as a screening model for antidepressants. In the present experiments, immobility was reduced by drugs which increase central dopaminergic and .alpha.-adrenergic activity, but was less affected by drugs which act mainly on central serotonin. Immobility could be increased by drugs which diminish central catecholamine activity but not by drugs which inhibit central serotonin. Apparently immobility depended primarily on the activity of central catecholamines, but caution was required before ascribing immobility exclusively to activity within a single system.