A role for calsenilin and related proteins in multiple aspects of neuronal function
A role for calsenilin and related proteins in multiple aspects of neuronal function
复制标题
DOI：
10.1016/j.bbrc.2004.08.001
复制
发表时间：
2004-10-01
影响因子：
3.1
通讯作者：
Buxbaum, JD
中科院分区：
文献类型：
--
作者：
Buxbaum, JD
这种蛋白质被分别称为calsenilin、DREAM或KChIP 3，已经被独立地发现了三次，这也是目前使用的三个不同名称的原因。Calsenilin似乎有三个，也许是独立的，作用。钙生素结合并调节阿尔茨海默病相关蛋白早老素的一些作用，而早老素可以调节钙生素的一些作用。钙senilin结合强啡肽反应元件并调节强啡肽表达，从而调节伤害感受。钙senilin结合Kv通道并调节钾传导，在长时程增强以及其他重要的可塑性途径中发挥作用。钙senilin家族的其他成员至少具有部分作用。例如，KChIP1、KChIP2和卡尔普都可以结合早老素，并且都可以调节A型钾通道。进一步的功能解剖这个家庭的蛋白质将提供洞察神经元功能的许多方面，并将阐明钙蛋白家族的蛋白质在疾病中的作用。(C)2004年爱思唯尔公司All rights reserved.
The protein variously called calsenilin, DREAM, or KChIP3 has been independently discovered three times, accounting for the three different names currently in use. Calsenilin appears to have three, perhaps independent, roles. Calsenilin binds and modulates some of the effects of the Alzheimer disease-related protein presenilin, while presenilin can modulate some of the effects of calsenilin. Calsenilin binds the dynorphin response element and regulates dynorphin expression, hence regulating nociception. Calsenilin binds Kv channels and modulates potassium conductance, playing a role in long-term potentiation as well as in other important plastic pathways. Other members of the calsenilin family share at least some of the roles. For example, KChIPI, KChIP2, and CALP can all bind presenilins and can all modulate A-type potassium channels. Further functional dissection of this family of proteins will provide insight into numerous aspects of neuronal function and will illuminate the role of the calsenilin family of proteins in disease. (C) 2004 Elsevier Inc. All rights reserved.