Role of intraoral color Doppler sonography in predicting delayed cervical lymph node metastasis in patients with early-stage tongue cancer: a pilot study
Role of intraoral color Doppler sonography in predicting delayed cervical lymph node metastasis in patients with early-stage tongue cancer: a pilot study
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DOI：
10.1016/j.oooo.2014.10.021
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发表时间：
2015-02-01
影响因子：
2.9
通讯作者：
Ariji, Eiichiro
中科院分区：
文献类型：
--
作者：
Ariji, Yoshiko;Goto, Mitsuo;Ariji, Eiichiro
Objective.目的：探讨舌癌口内彩色多普勒超声声像图特征与颈淋巴结转移的关系。入组了31例T1-2 N 0舌鳞状细胞癌患者（24例男性和7例女性; 32-87岁;中位数60.6岁）。收集术前临床信息和超声检查结果。随访2年以上，观察是否有迟发性淋巴结转移。我们评估了与淋巴结转移相关的重要临床和超声因素。有颈淋巴结转移者与无颈淋巴结转移者在肿瘤最大、最小大小、临床类型、肿瘤深度和厚度、肿瘤侵润前沿形态、肿瘤区血管指数（VI）、舌深动脉VI不对称性等方面差异有统计学意义。在预测淋巴结转移的受试者工作特征（ROC）曲线分析中，肿瘤厚度的曲线下面积（AUC）和肿瘤面积的VI分别为0.861和0.909。VI的AUC值略高，但差异不显著（P = 0.532）。建议经口彩色多普勒超声检查，因为它可以识别颈淋巴结转移的预测因素。
Objective. To clarify the intraoral color Doppler sonographic features of tongue cancer in relation to cervical lymph node metastasis.Study Design. Thirty-one patients (24 men and 7 women; 32-87 years old; median 60.6 years) with T1-2 N0 squamous cell carcinoma of the tongue were enrolled. Preoperative clinical information and sonographic findings were collected. Patients were followed up for 2 years or more, and the presence of delayed lymph node metastasis was investigated. Significant clinical and sonographic factors were evaluated in relation to lymph node metastasis.Results. Significant differences in maximum and minimum tumor size, clinical type, tumor depth and thickness, shape of the invading front of the tumor, vascular index (VI) of the tumor area, and asymmetry of the VI of the deep lingual artery were observed between patients with cervical lymph node metastasis and those without. The areas under the curve (AUCs) of tumor thickness and the VI of the tumor area were 0.861 and 0.909, respectively, on receiver operating characteristic (ROC) curve analysis for predicting lymph node metastasis. The AUC for the VI showed a slightly higher value, although the difference was not significant (P = .532).Conclusions. Intraoral color Doppler sonography is recommended, as it may identify predictive factors of cervical lymph node metastasis.