Multicellular sensing at a feedback-induced critical point
Multicellular sensing at a feedback-induced critical point
复制标题
反馈诱导临界点的多细胞传感
DOI：
10.1103/physreve.102.052411
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发表时间：
2020
影响因子：
2.4
通讯作者：
Mugler, Andrew
中科院分区：
文献类型：
--
作者：
Vennettilli, Michael;Erez, Amir;Mugler, Andrew
感觉生化网络中的反馈会导致细胞行为反应的分叉。这些分叉与热力学临界点有许多共同的性质。有证据表明，生物系统可能在这些临界点附近运行，但这样做的功能好处仍然知之甚少。在这里，我们研究了一个具有非线性反馈和多细胞通讯的简单生化模型，以确定临界程度是否在获得关于随机化学信号的信息方面提供了功能上的好处。我们发现，当信号波动较慢时，信号和细胞内读数之间的互信息在临界点最大化，因为高信号敏感度的好处超过了高读出噪声的坏处。当细胞通信时，临界性会在细胞间读出的分子数中产生远程关联。因此，我们发现，通信增加了给定细胞读数和整个种群中信号的空间平均之间的互信息。最后，我们发现，无论有没有交流，临界性的感官益处都与临界性的减慢相竞争，使得信息速率在临界点被最小化，而不是信息本身。我们的结果揭示了反馈诱导的多细胞传感临界性的成本和收益。
Feedback in sensory biochemical networks can give rise to bifurcations in cells' behavioral response. These bifurcations share many properties with thermodynamic critical points. Evidence suggests that biological systems may operate near these critical points, but the functional benefit of doing so remains poorly understood. Here we investigate a simple biochemical model with nonlinear feedback and multicellular communication to determine if criticality provides a functional benefit in terms of the ability to gain information about a stochastic chemical signal. We find that when signal fluctuations are slow, the mutual information between the signal and the intracellular readout is maximized at criticality, because the benefit of high signal susceptibility outweighs the detriment of high readout noise. When cells communicate, criticality gives rise to long-range correlations in readout molecule number among cells. Consequently, we find that communication increases the mutual information between a given cell's readout and the spatial average of the signal across the population. Finally, we find that both with and without communication, the sensory benefits of criticality compete with critical slowing down, such that the information rate, as opposed to the information itself, is minimized at the critical point. Our results reveal the costs and benefits of feedback-induced criticality for multicellular sensing.