Extinction under a behavioral microscope: Isolating the sources of decline in operant response rate
Extinction under a behavioral microscope: Isolating the sources of decline in operant response rate
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DOI：
10.1016/j.beproc.2012.02.012
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发表时间：
2012-05-01
影响因子：
1.3
通讯作者：
Sanabria, Federico
中科院分区：
文献类型：
--
作者：
Cheung, Timothy H. C.;Neisewander, Janet L.;Sanabria, Federico
消退表现通常用于评估潜在的心理过程，而不受强化的干扰。例如，在消退/恢复范式中，通过测量由药物相关线索引起的反应来评估寻求药物的动机，而无需药物强化。然而，灭绝的表现是由几个心理过程，涉及动机，记忆，学习和运动功能。当使用总体响应率来衡量性能时，这些过程会混淆。基于操作性反应发生在发作中的证据，本文提出了一个分析程序，将消退表现分为几个行为成分：（1-3）消退开始时的基线发作启动率、发作内反应率和发作长度，（4-6）消退过程中它们的衰减率，（7）消退开始和反应下降之间的时间，（8）消退开始和反应下降之间的时间，（9）消退开始和反应下降之间的时间，（10）消退开始和反应下降之间的时间。（8）消退结束时的渐近反应率;（9）每次反应后的不应期。数据说明了这个分析模型的拟合优度。本文还介绍了程序隔离行为组件的消光性能，并对这些组件的实验效果进行推断。这种微观行为分析允许将不同的心理过程映射到与灭绝表现有关的不同行为成分，这可能会进一步加深我们对神经生物学治疗的心理影响的理解。(C)2012爱思唯尔有限公司版权所有。
Extinction performance is often used to assess underlying psychological processes without the interference of reinforcement. For example, in the extinction/reinstatement paradigm, motivation to seek drug is assessed by measuring responding elicited by drug-associated cues without drug reinforcement. However, extinction performance is governed by several psychological processes that involve motivation, memory, learning, and motoric functions. These processes are confounded when overall response rate is used to measure performance. Based on evidence that operant responding occurs in bouts, this paper proposes an analytic procedure that separates extinction performance into several behavioral components: (1-3) the baseline bout initiation rate, within-bout response rate, and bout length at the onset of extinction; (4-6) their rates of decay during extinction; (7) the time between extinction onset and the decline of responding; (8) the asymptotic response rate at the end of extinction; (9) the refractory period after each response. Data that illustrate the goodness of fit of this analytic model are presented. This paper also describes procedures to isolate behavioral components contributing to extinction performance and make inferences about experimental effects on these components. This microscopic behavioral analysis allows the mapping of different psychological processes to distinct behavioral components implicated in extinction performance, which may further our understanding of the psychological effects of neurobiological treatments. (C) 2012 Elsevier B.V. All rights reserved.