Estimating the probability of allelic drop-out of STR alleles in forensic genetics
Estimating the probability of allelic drop-out of STR alleles in forensic genetics
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DOI：
10.1016/j.fsigen.2009.02.002
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发表时间：
2009-09-01
影响因子：
3.1
通讯作者：
Morling, Niels
中科院分区：
文献类型：
--
作者：
Tvedebrink, Torben;Eriksen, Poul Svante;Morling, Niels
在有可用 DNA 证据的犯罪案件中，由于犯罪背景的原因，DNA 的数量往往很少。在这种情况下，STR 分型中一个或多个真实等位基因的等位基因丢失是可能的。我们提出了一个统计模型，以病例样本中所有 STR 位点的结果作为参考，估计每个位点和等位基因丢失的总体概率。逻辑回归的方法适合这种分析，我们演示了如何将其纳入法医遗传框架中。 (C) 2009 Elsevier Ireland Ltd. 保留所有权利。
In crime cases with available DNA evidence, the amount of DNA is often sparse due to the setting of the crime. In such cases, allelic drop-out of one or more true alleles in STR typing is possible. We present a statistical model for estimating the per locus and overall probability of allelic drop-out using the results of all STR loci in the case sample as reference. The methodology of logistic regression is appropriate for this analysis, and we demonstrate how to incorporate this in a forensic genetic framework. (C) 2009 Elsevier Ireland Ltd. All rights reserved.