Anticancer drug design based on plant-derived natural products.
Anticancer drug design based on plant-derived natural products.
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DOI：
10.1007/bf02253565
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发表时间：
1999-07
影响因子：
11
通讯作者：
K. Lee
中科院分区：
文献类型：
--
作者：
K. Lee
本文综述了近年来我实验室对具有有效抗肿瘤活性的各类化合物的研究进展。这些化合物是通过生物活性和机制导向的分离和表征，结合合理的药物设计修饰和类似物合成得到的。本文将讨论结构修饰、构效关系和作用机理的研究。
This review article focuses on recent research in my laboratory on various classes of compounds that possess potent antitumor activity. These compounds were obtained by bioactivity- and mechanism of action-directed isolation and characterization coupled with rational drug design-based modification and analog synthesis. Structural modification, structure-activity relationship, and mechanism of action studies will be discussed.