INCREASED CONCENTRATIONS OF PHOSPHATIDYLINOSITOL (PI) AND DECREASED ESTERIFICATION OF ARACHIDONIC-ACID INTO PHOSPHOLIPIDS IN PLATELETS FROM PATIENTS WITH SCHIZOAFFECTIVE DISORDERS OR ATYPIC PHASIC PSYCHOSES
INCREASED CONCENTRATIONS OF PHOSPHATIDYLINOSITOL (PI) AND DECREASED ESTERIFICATION OF ARACHIDONIC-ACID INTO PHOSPHOLIPIDS IN PLATELETS FROM PATIENTS WITH SCHIZOAFFECTIVE DISORDERS OR ATYPIC PHASIC PSYCHOSES
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DOI：
10.1016/0952-3278(92)90058-q
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发表时间：
1992-05-01
影响因子：
3
通讯作者：
KIRSTEN, R
中科院分区：
文献类型：
--
作者：
DEMISCH, L;HEINZ, K;KIRSTEN, R
测定血小板中各种磷脂(PL)和鞘磷脂的浓度以及[C-14]花生四烯酸([C-14]-AA)在磷脂酰肌醇(PI)、磷脂酰丝氨酸(PS)、磷脂酰乙醇胺(PE)和磷脂酰胆碱(PC)中的酯化量。用1-MU-M[C-14]-AA与未用药的精神障碍患者和健康对照的富含血小板血浆孵育30min。根据RDC标准的分裂情感障碍患者、分裂样障碍(DSM III标准)或FC标准的非典型相态精神病患者的血小板含有的PI是对照组的两倍，PC浓度显著高于对照组(p<；0.05，t检验)。[C-14]-AA酯化为PI/PS、PC和PE的速率在分裂样、分裂情感性和重度抑郁症患者的血小板中显著降低(40-70%)，而在慢性精神分裂症患者的血小板中无显著差异。分裂情感性障碍患者血小板PI/PS中[C-14]-AA的酯化降低幅度最大(约70%)(1.9+/-0.7vs6.3+/-1.7-mU-moL[C-14]-AA/molPI/PS；p<；10(-4)，t检验)。结果表明，血小板中花生四烯酸和磷脂酰肌醇的代谢变化，以及较小程度的磷脂酰胆碱的代谢变化，是精神病患者可能有良好预后的特征。
The concentration of various phospholipids (PLs) and sphingomyelin in platelets and the amount of [C-14] arachidonic acid ([C-14]-AA) esterified in phosphatidylinositol (PI), phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylcholine (PC) were measured. The platelet-rich plasmas from unmedicated patients with psychiatric disorders and healthy controls were incubated for 30 min with 1-mu-M [C-14]-AA. Platelets from patients with a schizoaffective disorder according to RDC criteria, a schizophreniform disorder (DSM III criteria) or an atypical phasic psychosis according to FC criteria contained twice as much PI and had significantly increased concentrations of PC as compared to controls (p < 0.05, t-test). A highly significant (40-70%) reduced rate of esterification of [C-14]-AA into PI/PS, PC and PE was found in platelets from patients with schizophreniform, schizoaffective and major depressive disorders but not in platelets from patients with chronic schizophrenia. The largest reduced esterification of [C-14]-AA (about 70%) was found in PI/PS of platelets from patients with schizoaffective disorders (1.9 +/- 0.7 vs 6.3 +/- 1.7-mu-mol [C-14]-AA/mol PI/PS; p < 10(-4), t-test). The results indicate that changes in the metabolism of arachidonic acid and phosphatidylinositol and, to a lesser degree, of phosphatidylcholine in platelets are characteristic of patients with a likely favorable outcome of a psychotic episode.