Disparate outcomes in pediatric peritoneal dialysis patients by gender/race in the End-Stage Renal Disease Clinical Performance Measures project.
Disparate outcomes in pediatric peritoneal dialysis patients by gender/race in the End-Stage Renal Disease Clinical Performance Measures project.
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在终末期肾病临床表现测量项目中，不同性别/种族的儿科腹膜透析患者的结果存在差异。
DOI：
10.1007/s00467-008-0832-z
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
Frankenfield,DianeL
中科院分区：
文献类型：
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作者：
Atkinson,MeredithA;Neu,AliciaM;Fivush,BarbaraA;Frankenfield,DianeL
对2004年10月至2005年3月期间终末期肾病（ESRD）临床性能指标（CPM）项目中的小儿腹膜透析患者，确定了成人肾脏疾病结局质量倡议（KDOQI）血红蛋白、充足性和白蛋白目标的实现与种族和性别之间的关系。五十六%（427/761）的患者为男性。66%（500/761）的患者为白色。按性别划分的成人目标实现情况无差异，按种族划分的充足性参数无差异。黑人的平均血红蛋白水平低于白人（11.1 ± 1.6 g/dl vs 11.8 ± 1.4 g/dl，P< 0.0001）。黑人平均血红蛋白水平< 10 g/dl的可能性更大（24%vs11%，P < 0.0001），平均血红蛋白水平> 11 g/dl的可能性更小（56%vs72%，P < 0.0001）。白人比黑人更容易达到平均血清白蛋白水平> 4.0/3.7 g/dl [溴甲酚绿色/溴甲酚紫（BCG/BCP）]（35%vs 26%，P = 0.0376）。在多变量逻辑回归模型中，白色人种与平均血红蛋白水平> 11 g/dl [调整后的比值比（adjOR）2.7，95%置信区间（CI）1.7，4.3]和平均血清白蛋白> 4.0/3.7 g/dl（BCG/BCP）（adjOR 1.9，95% CI 1.3，2.9）相关。腹膜透析贫血的相关因素及纠正的障碍有待进一步研究。
Associations between achievement of adult Kidney Disease Outcomes Quality Initiative (KDOQI) targets for hemoglobin, adequacy and albumin, and race and gender were determined for pediatric peritoneal dialysis patients from the End-Stage Renal Disease (ESRD) Clinical Performance Measures (CPM) project for the period October 2004–March 2005. Fifty-six percent (427/761) of patients were male. Sixty-six percent (500/761) of patients were White. There were no differences in achievement of targets for adults by gender, and no differences in adequacy parameters by race. Blacks had lower mean hemoglobin levels than did Whites (11.1 ± 1.6 g/dl vs 11.8 ± 1.4 g/dl,P< 0.0001). Blacks were more likely to have mean hemoglobin levels < 10 g/dl (24% vs 11%,P< 0.0001) and less likely to achieve mean hemoglobin > 11 g/dl (56% vs 72%,P< 0.0001). Whites were more likely to achieve mean serum albumin levels > 4.0/3.7 g/dl [bromocresol green/bromocresol purple (BCG/BCP)] than Blacks were (35% vs 26%,P= 0.0376). In multivariate logistic regression models, White race was associated with mean hemoglobin levels > 11 g/dl [adjusted odds ratio (adjOR) 2.7, 95% confidence interval (CI) 1.7, 4.3] and mean serum albumin > 4.0/3.7 g/dl (BCG/BCP) (adjOR 1.9, 95% CI 1.3, 2.9]. Further study is needed of factors associated with anemia on peritoneal dialysis and barriers to its correction.