The significance of nerve sugar levels for the peripheral nerve impairment of spontaneously diabetic GK (Goto-Kakizaki) rats.
The significance of nerve sugar levels for the peripheral nerve impairment of spontaneously diabetic GK (Goto-Kakizaki) rats.
复制标题
神经糖水平对自发性糖尿病 GK（Goto-Kakizaki）大鼠周围神经损伤的意义。
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
K. Okada
中科院分区：
文献类型：
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作者：
K. Suzuki;H. Yen;T. Toyota;Y. Gotō;Y. Hirata;K. Okada
本研究旨在阐明自发性糖尿病GK（Goto-Kakizaki）大鼠运动神经传导速度减慢与山梨醇、果糖、葡萄糖和肌醇的神经水平之间的关系。 GK 大鼠的运动神经传导速度在三月龄和九月龄时持续低于正常对照组。 GK 大鼠运动神经传导速度的持续降低与 GK 大鼠出生后不久的葡萄糖耐受不良密切相关。与正常对照组相比，GK大鼠9个月时山梨醇、葡萄糖和果糖的神经水平显着升高，但3个月时则没有（葡萄糖除外）。 GK 大鼠的神经糖浓度随着年龄的增长而逐渐增加。然而，正常 Wistar 大鼠的葡萄糖、山梨醇和果糖水平随着年龄的增长而保持不变。尽管 GK 大鼠的神经肌醇水平在 3 个月和 9 个月时低于正常对照组，但仅在 9 个月时观察到肌醇水平存在显着差异。相反，正常Wistar大鼠的神经肌醇水平没有表现出与年龄相关的变化。这些发现表明，多元醇途径活性的增强和肌醇的消耗在运动神经传导速度的降低中发挥着重要作用。
This study was carried out to clarify the relationship between the slowing of motor nerve conduction velocity and nerve levels of sorbitol, fructose, glucose and myoinositol in spontaneously diabetic GK (Goto-Kakizaki) rats. The motor nerve conduction velocity in GK rats was constantly lower than in normal controls at three and nine months of age. This constant decrease in motor nerve conduction velocity in GK rats was closely related to glucose intolerance in GK rats soon after birth. Nerve levels of sorbitol, glucose and fructose in GK rats were significantly increased as compared to normal controls at nine months old, but not (except glucose) at three months old. The increase in nerve concentrations of sugars in GK rats was progressive with age. However, levels of glucose, sorbitol and fructose in normal Wistar rats remain unchanged with age. Although nerve myo-inositol levels in GK rats were lower at three and nine months than those of normal controls, a significant difference in myo-inositol levels was observed only at nine months. On the contrary, nerve myo-inositol level in normal Wistar rats did not show age-related change. These findings suggested that both enhanced polyol pathway activity and myo-inositol depletion play important roles in the reduction of motor nerve conduction velocity.