Pediatric Rhabdomyosarcoma.
Pediatric Rhabdomyosarcoma.
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DOI：
10.1615/critrevoncog.2015013800
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发表时间：
2015
影响因子：
--
通讯作者：
Khan J
中科院分区：
文献类型：
--
作者：
Shern JF;Yohe ME;Khan J
横纹肌肉瘤是儿童最常见的软组织肉瘤，尽管临床进展，这些患者的子集继续遭受高水平的发病率和死亡率与他们的疾病。最近使用复杂的基因组学技术（包括下一代测序实验）对这些肿瘤进行的遗传和分子表征揭示了可以用于这种疾病的新分子靶向疗法的多个领域。
Rhabdomyosarcoma is the most common soft-tissue sarcoma of childhood, and despite clinical advances, subsets of these patients continue to suffer high levels of morbidity and mortality associated with their disease. Recent genetic and molecular characterization of these tumors using sophisticated genomics techniques, including next-generation sequencing experiments, has revealed multiple areas that can be exploited for new molecularly targeted therapies for this disease.