A Single Arm Pilot Study of Effects of Berberine on the Menstrual Pattern, Ovulation Rate, Hormonal and Metabolic Profiles in Anovulatory Chinese Women with Polycystic Ovary Syndrome.
A Single Arm Pilot Study of Effects of Berberine on the Menstrual Pattern, Ovulation Rate, Hormonal and Metabolic Profiles in Anovulatory Chinese Women with Polycystic Ovary Syndrome.
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小檗碱对患有多囊卵巢综合症的无排卵中国女性的月经模式、排卵率、激素和代谢特征影响的单臂初步研究
DOI：
10.1371/journal.pone.0144072
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Yang D
中科院分区：
文献类型：
--
作者：
Li L;Li C;Pan P;Chen X;Wu X;Ng EH;Yang D
评估小檗碱对患有多囊卵巢综合征的无排卵中国女性的月经模式、排卵率、激素和代谢特征的影响。对 102 名无排卵的中国多囊卵巢综合征女性给予小檗碱 0.4 g，每天 3 次，为期 4 个月。比较小檗碱治疗前后的月经模式、排卵率、激素和代谢特征。血清孕酮水平≥10ng/ml即可确认排卵。 102 名受试者中共有 98 名受试者 (96.1%) 完成了四个月的治疗，其中 69 名受试者 (70.4%, 69/98) 体重正常，29 名受试者 (29.6%, 29/98) 超重/肥胖。 14 名女性（14.3%，14/98）在小檗碱治疗后恢复了正常月经，正常体重组和超重/肥胖组之间没有显着差异。全组4个月排卵率为25.0%，正常体重组为22.5%，超重/肥胖组为31.0%。仅在正常体重组中，小檗碱治疗后性激素结合球蛋白、胰岛素抵抗、总胆固醇、总甘油三酯和低密度脂蛋白胆固醇降低。我们的研究发现，单独服用小檗碱可以改善患有多囊卵巢综合征的无排卵中国女性的月经模式和排卵率。小檗碱还可以降低正常体重的多囊卵巢综合征女性的性激素结合球蛋白、胰岛素抵抗、总胆固醇、甘油三酯和低密度脂蛋白胆固醇。 Chictr.org ChiCTR-OO-13003943
To evaluate the effects of berberine on the menstrual pattern, ovulation rate, hormonal and metabolic profiles in anovulatory Chinese women with polycystic ovary syndrome. Berberine 0.4 g three times per day was given for four months to 102 anovulatory Chinese women with polycystic ovary syndrome. The menstrual pattern, ovulation rate, hormonal and metabolic profiles were compared before and after the berberine treatment. Ovulation was confirmed by serum progesterone level ≥10ng/ml. A total of 98 of 102 subjects (96.1%) completed the four month treatment, including 69 (70.4%, 69/98) normal weight and 29 (29.6%, 29/98) overweight/obese. Fourteen women (14.3%, 14/98) had regained regular menses after berberine treatment and there was no significant difference between normal weight and overweight/obese groups. The ovulation rate was 25.0% over four months in the whole group, 22.5% in the normal weight group and 31.0% in the overweight/obese group. Sex hormone binding globulin, insulin resistance, total cholesterol, total triglyceride and low-density lipoprotein cholesterol decreased after berberine treatment in the normal weight group only. Our study found that administration of berberine alone may improve the menstrual pattern and ovulation rate in anovulatory Chinese women with polycystic ovary syndrome. Berberine can also decrease sex hormone binding globulin, insulin resistance, total cholesterol, triglycerides and low-density lipoprotein cholesterol in normal weight polycystic ovary syndrome women. Chictr.org ChiCTR-OO-13003943