Comparing the outcomes of radiofrequency ablation and surgery in patients with a single small hepatocellular carcinoma and well-preserved hepatic function
Comparing the outcomes of radiofrequency ablation and surgery in patients with a single small hepatocellular carcinoma and well-preserved hepatic function
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DOI：
10.1097/01.mcg.0000152746.72149.31
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发表时间：
2005-03-01
影响因子：
2.9
通讯作者：
Joh, JW
中科院分区：
文献类型：
--
作者：
Hong, SN;Lee, SY;Joh, JW
目的：比较射频消融与外科手术治疗肝细胞癌的疗效。结果：射频消融组局部复发率明显高于手术组(P=0.005)，射频消融组局部复发率显著高于手术组(P=0.005)，射频消融治疗组局部复发率明显高于手术组(P=0.05)。两组的远期复发率相似(P=0.30)。两组的1、3年累计总生存率(P=0.24)和累计1、3年无复发生存率(P=0.54)无显著差异。结论：尽管局部复发率较高，但对于肝功能保存良好的单发小肝癌患者，在远期复发率和总体和(或)无复发生存的可能性方面，RFA与手术切除的疗效相当。
Goals: To compare the efficacy of radiofrequency ablation (RFA) and surgical resection in a group of patients with a Child-Pugh score of 5 and a single HCC less than 4 cm in diameter.Background: Radiofrequency ablation (RFA) has become a popular method for treatment of hepatocellular carcinoma (HCC) and has been applied as an alternative primary therapy to surgical resection.Study: We compared outcomes for 148 patients treated with RFA (n = 55) and those treated surgically (n = 93).Results: The rate of local recurrence among patients in the RFA group was significantly higher than in the surgery group (P = 0.005), while the incidence of remote recurrence was similar between the two lgroups (P = 0.30). The curnulative 1- and 3-year overall Survival rates (P = 0.24) and the cumulative 1- and 3-year recurrence-free survival rates (P = 0.54) were not significantly different between the two groups.Conclusions: Despite a higher rate of local recurrence, RFA was found to be as effective as surgical resection for the treatment of single small HCC in patients with well-preserved liver function, in terms of the incidence of remote recurrence and the patients' likelihood of achieving overall and/or recurrence-free survival.