Combined therapy for hypopharyngeal cancer.
Combined therapy for hypopharyngeal cancer.
复制标题
下咽癌的联合治疗。
DOI：
10.3109/00016489609124354
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
T. Makoshi
中科院分区：
文献类型：
--
作者：
M. Okamoto;H. Takahashi;K. Yao;K. Inagi;M. Nakayama;T. Makoshi
我们研究了69名在1979年到1992年间接受治疗的下咽癌患者。5年累计生存率为53%。I期5例，II期7例，III期20例，IV期37例；I期、II期、III期和IV期的生存率分别为80%、54%、61%和47%。25例术前放疗（小于40 Gy）后全咽-喉-食管切除术的5年生存率为59%。44例患者以放射治疗为主。从保留声带功能的角度出发，我们建议将根治性放疗作为首选治疗方法。5年生存率为48%。放射治疗失败16例，其中2例拒绝手术。14例（36%）行挽救性手术，生存率为36%。30例未接受手术的患者生存率为61%；以姑息治疗为目的接受手术的患者和拒绝接受手术的患者被纳入这一组。与以往的研究结果相比，本研究的两种治疗方案均显示出更高的生存率。我们的结论是，改善的结果是由于正确的治疗选择，特别是对患者免疫反应的关注和由于颈部淋巴结转移而导致的最小死亡。
We studied 69 hypopharyngeal cancer patients who were treated between 1979 and 1992. The 5-year cumulative survival rate was 53%. There were five stage I, seven stage II, 20 stage III and 37 stage IV patients; survival rates for stages I, II, III, and IV were 80%, 54%, 61% and 47%, respectively. The 5-year survival rate for the 25 patients who received preoperative radiotherapy (fewer than 40 Gy) followed by total pharyngo-laryngo-esophagectomy was 59%. Forty-four patients received radical radiotherapy as a main treatment. From the standpoint of preserving vocal function, we recommend using the radical radiation as a first-choice treatment. The 5-year survival rate was 48%. There were 16 radiation failure patients after radical radiotherapy and two of them refused to have surgery. Fourteen patients (36%) received a salvage operation and the survival rate was 36%. The survival rate for the 30 patients who did not receive surgery was 61%; the patients who received surgery as a palliative purpose and the patients who refused to undergo surgery were included in this group. Both treatment regimens of the present study showed higher survival rates compared to the results of previous studies. We concluded that the improved results were due to the proper selection of the treatment, especially the attention given to the patient's immune response and the minimum death as a result of neck node metastasis.