Mannose‐specific oligosaccharide recognition by mononuclear phagocytes
Mannose‐specific oligosaccharide recognition by mononuclear phagocytes
复制标题
单核吞噬细胞对甘露糖特异性寡糖的识别
DOI：
10.1111/j.1768-322x.1984.tb00301.x
复制
发表时间：
1984
影响因子：
2.7
通讯作者：
V. Shepherd
中科院分区：
文献类型：
--
作者：
P. Stahl;T. Wileman;S. Diment;V. Shepherd
Glycoproteins terminating in mannose are recognized by receptors on macrophages. The mannose receptor is expressed by a variety of macrophages but expression is closely regulated. Activated macrophages, for example, express little mannose receptor activity. Kinetic and fractionation experiments suggest that cell surface mannose receptors recycle to and from an acidic, pre‐lysosomal compartment. Preliminary evidence suggests that the mannose receptor is a large polypeptide and that it is structurally related to the mannose binding protein found in serum. The mannose receptor may, among other possibilities, regulate the extracellular levels of lysosomal hydrolases.
