Comparative studies on the effects of semipurified and commercial diet on longevity and spontaneous and induced lesions in the Syrian golden hamster.
Comparative studies on the effects of semipurified and commercial diet on longevity and spontaneous and induced lesions in the Syrian golden hamster.
复制标题
半纯化和商业饮食对叙利亚金仓鼠寿命以及自发性和诱发性病变影响的比较研究。
DOI：
10.1080/01635588509513851
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
P. Pour
中科院分区：
文献类型：
--
作者：
D. Birt;K. Patil;P. Pour
叙利亚金黄仓鼠在整个生命过程中都被喂以半纯或商业饲料断奶。8周龄时皮下注射双(2-氧丙基)亚硝胺(BOP)10 mg/kg体重。饲喂半纯饲料的雄性和雌性仓鼠的平均寿命分别提高了26%和36%。致癌物治疗并没有改变患者的存活率。在喂食商业饲料的仓鼠中，年龄调整后的胰管增生、癌、腺瘤和胆总管息肉的发生率更高；这表明喂食这种饮食的仓鼠出现这些BOP诱导的病变的时间更早。然而，当两个节食组进行比较时，他们的总体发病率总体上是相似的。腺泡细胞结节只在饲喂半纯饲料的仓鼠中观察到，而在接受BOP处理的雌性仓鼠中则升高。雌性仓鼠的胰管增生和腺瘤、胆管增殖、甲状旁腺增生和胆总管乳头状增生的发病时间均早于雄性仓鼠，尤其是在饲喂商业日粮的组。在饲喂商品日粮的仓鼠中，观察到全身性血管钙化的比率较高，总体发病率较高。年龄调整后的淀粉样变性率在雌性仓鼠中很高，在食用商业日粮的组中升高。此外，在饲喂商品日粮的仓鼠中，结肠炎和胰岛细胞增生的发生率更高和更早，但胆结石在饲喂半纯饲料的动物中最多。本文讨论了这些与其他观察到的病变和存活率之间的可能联系。
Syrian golden hamsters were fed a semipurified or commercial diet from weaning throughout life. Bis(2-oxopropyl)nitrosamine (BOP) was administered at 8 weeks of age (10 mg/kg body wt, sc). Longevity was improved by 26% and 36% increases in the mean life-spans of male and female hamsters, respectively, fed the semipurified diets. Carcinogen treatment did not alter survival. The age-adjusted occurrence rates of pancreatic ductular proliferation, carcinomas, adenomas, and common duct polyps were higher in hamsters fed commercial diet; this indicates an earlier onset of these BOP-induced lesions in hamsters fed this diet. However, their overall incidences were generally similar when the two diet groups were compared. Acinar cell nodules were observed only in hamsters fed semipurified diets and were elevated in BOP-treated females. The onset of pancreatic ductular proliferation and adenomas, bile duct proliferation, parathyroid hyperplasia, and common duct papillary hyperplasia was earlier in females than in male hamsters, especially in groups fed commercial ration. Generalized vascular calcification was observed at an elevated rate and reached a higher overall incidence in hamsters fed commercial ration. The age-adjusted rate of amyloidosis was high in female hamsters and elevated in groups that consumed the commercial ration. In addition, colitis and islet cell hyperplasia occurred more often and earlier in hamsters fed commercial ration, but gallbladder stones occurred most in animals fed semipurified diet. This paper discusses the possible association between these and other observed lesions and survival.