Regional circulatory responses to hindlimb work in developing swine.
Regional circulatory responses to hindlimb work in developing swine.
复制标题
猪发育过程中后肢的区域循环反应。
DOI：
10.1159/000243270
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Frasier,ID
中科院分区：
文献类型：
--
作者：
Buckley,NM;Frasier,ID
采用戊巴比妥麻醉29头猪（1日龄~ 1月龄），研究了后肢运动对循环系统的影响。测定坐骨远端神经刺激前后不同后肢耗氧水平下股骨、肾脏和肠道血流量、阻力和自身调节能力。在所有年龄的动物中，氧气消耗的增加都伴随着充血，但只有在2周和1个月大的动物中才会增加氧气提取，没有自我调节的证据。只有在新生儿中，血流才持续地从肾脏和小肠重新分配。在整个实验过程中，老年动物的肾脏和肠道血流通常保持自我调节。我们的结论是，后肢运动唤起了与年龄相关的区域血流调节，反映了神经和自我调节控制的平衡。
Circulatory effects of hindlimb work were studied in 29 swine (aged 1 day to 1 month) anesthetized with pentobarbital. Femoral, renal and intestinal blood flow, resistance and autoregulatory capability were determined at different levels of hindlimb oxygen consumption before and during distal sciatic nerve stimulation. Increases in oxygen consumption were accompanied by hyperemia at all ages, but by increased oxygen extraction only in 2-week and 1-month-old animals, without evidence of autoregulation. Blood flow was consistently redistributed from the kidney and small intestine only in neonates. Older animals generally sustained autoregulation of renal and intestinal blood flows throughout experiments. We concluded that hindlimb work evokes age-related adjustments in regional blood flow that reflect the balance of neural and autoregulatory control.