Recombinant antibodies generated from both clonal and less abundant plasma cell immunoglobulin G sequences in subacute sclerosing panencephalitis brain are directed against measles virus
Recombinant antibodies generated from both clonal and less abundant plasma cell immunoglobulin G sequences in subacute sclerosing panencephalitis brain are directed against measles virus
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DOI：
10.1080/13550280600957414
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发表时间：
2006-10-01
影响因子：
3.2
通讯作者：
Owens, Gregory P.
中科院分区：
文献类型：
--
作者：
Burgoon, Mark P.;Caldas, Yupanqui A.;Owens, Gregory P.
增加的免疫球蛋白G（IgG）和鞘内产生的寡克隆带（OGB）是少数炎性中枢神经系统（CNS）疾病的特征，通常针对疾病的原因。在亚急性硬化性全脑炎（SSPE）中，疾病的原因和寡克隆应答的靶点是麻疹病毒（MV）。作者先前表明，SSPE脑中CD38+浆细胞的克隆扩增群体（OGB的可能来源）针对MV。在表征浆细胞反应性的广度时，作者发现大部分丰度较低的浆细胞也针对MV。鞘内反应可能有助于确定其他炎性CNS疾病的病因，如多发性硬化症、白塞氏病和神经结节病。
Increased immunoglobulin G (IgG) and intrathecally produced oligoclonal bands (OGBs) are characteristic of a limited number of inflammatory central nervous system (CNS) diseases and are often directed against the cause of disease. In subacute sclerosing panencephalitis (SSPE), the cause of disease and the target of the oligoclonal response is measles virus (MV). The authors previously showed that clonally expanded populations of CD38+ plasma cells in SSPE brain, the likely source of OGBs, are directed against MV. In characterizing the breadth of the plasma cell reactivities, the authors found that a large proportion of the less abundant plasma cells are also directed against MV. The intrathecal response may be useful in determining the causes of other inflammatory CNS diseases, such as multiple sclerosis, Behcet's disease, and neurosarcoidosis.