Airway remodelling in cough-variant asthma
Airway remodelling in cough-variant asthma
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DOI：
10.1016/s0140-6736(00)02584-8
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发表时间：
2000-08-12
期刊：
影响因子：
168.9
通讯作者：
Amitani, R
中科院分区：
文献类型：
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作者：
Niimi, A;Matsumoto, H;Amitani, R
上皮层增厚是气道重塑的病理特征，存在于咳嗽变异性哮喘中。在支气管活检样本中，我们发现咳嗽变异性哮喘患者的平均上皮下层厚度为7.1（SE 0.4）μ m，典型哮喘伴喘息患者为8.6（0.4）μ m，健康对照组为5.0（0.2）μ m。哮喘患者的厚度显著高于对照组，经典型哮喘患者的厚度显著高于咳嗽变异型哮喘患者。因此，早期抗炎治疗可能对咳嗽变异性哮喘有益，就像经典哮喘中推荐的那样。
Subepithelial-layer thickening, a pathological feature of airway remodelling, is present in cough-variant asthma. In bronchial biopsy samples we found mean subepithelial-layer thickness was 7.1 (SE 0.4) mu m in patients with cough-variant asthma, 8.6 (0.4) mu m in patients with classic asthma with wheezing, and 5.0 (0.2) mu m in healthy controls. Thickness was significantly higher in patients with asthma than in controls, and was significantly greater in those with classic asthma than in those with cough-variant asthma. Early anti-inflammatory treatment might, therefore, be beneficial in cough-variant asthma, as recommended in classic asthma.