Separation and identification of some chemical warfare degradation products using electrospray high resolution ion mobility spectrometry with mass selected detection
Separation and identification of some chemical warfare degradation products using electrospray high resolution ion mobility spectrometry with mass selected detection
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DOI：
10.1016/s0003-2670(99)00726-6
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发表时间：
2000-01-17
影响因子：
6.2
通讯作者：
Hill, HH
中科院分区：
文献类型：
--
作者：
Asbury, GR;Wu, C;Hill, HH
采用高分辨电喷雾离子迁移谱（IMS）分析了液体样品中的化学战降解产物。对于每种降解产物，测定了该技术的分析优值，并通过质谱法鉴别了每种响应离子。根据这些数据，首次计算了许多化合物的约化迁移率常数（K-0）。大多数化合物的检出限在正模式下小于1 ppm。更电负性的化合物，如膦酸被发现是更敏感的负模式与低ppb范围内的检测限。这项工作代表了负离子高分辨率离子迁移谱的第一个公布的数据，只有第二个出版物中，负离子已产生和检测使用大气压电喷雾离子迁移谱。线性响应范围通常约为两个数量级，动态响应范围约为四个数量级。四个降解产物的G-型神经毒剂不同，只有一个甲基与基线分辨率在不到15 ms的IMS分离。从加标的帕卢塞河水样品中分离并检测到相同的组分混合物，证明了该技术分析复杂基质中化学战降解产物的潜力。这是有史以来第一次发表的高分辨率大气压电喷雾离子迁移谱/质谱定量研究。（C）2000 Elsevier Science B. V.保留所有权利。
High resolution electrospray ion mobility spectrometry (IMS) was used to analyze chemical warfare degradation products from liquid samples. For each degradation product analytical figures of merit for the technique were determined and each response ion was identified by mass spectrometry. From these data, reduced mobility constants (K-0) for a number of compounds were calculated for the first time. The detection limits for most of the compounds were less than 1 ppm in the positive mode. The more electronegative compounds such as the phosphonic acids were found to be more sensitive in the negative mode with detection limits in the low ppb range. This work represents the first published data of negative ion high resolution ion mobility spectrometry and is only the second publication in which negative ions have been produced and detected using atmospheric pressure electrospray ion mobility spectrometry. Linear response ranges were generally about two orders of magnitude and dynamic response ranges were approximately four orders of magnitude. Four degradation products from the G-type nerve agent differing only by a methyl group were separated with baseline resolution in less than 15 ms by IMS. This same mixture of components was separated and detected from a spiked Palouse river water sample demonstrating the potential of the technique to analyze chemical warfare degradation products from complex matrices. This represents the first quantitative study ever published for high resolution atmospheric pressure electrospray ion mobility spectrometry/mass spectrometry. (C)2000 Elsevier Science B.V. All rights reserved.