The mammalian target of rapamycin signaling pathway: Twists and turns in the road to cancer therapy
The mammalian target of rapamycin signaling pathway: Twists and turns in the road to cancer therapy
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DOI：
10.1158/1078-0432.ccr-06-2798
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发表时间：
2007-06-01
影响因子：
11.5
通讯作者：
Gibbons, James J.
中科院分区：
文献类型：
--
作者：
Abraham, Robert T.;Gibbons, James J.
免疫抑制药物雷帕霉素在哺乳动物雷帕霉素靶蛋白(MTOR)的功能表征中起着关键作用，mTOR是一种不寻常的蛋白激酶，它协调生长因子和营养物质的供应与细胞的生长和增殖。一些与雷帕霉素相关的化合物目前正处于临床开发的不同阶段，作为抗癌药物。这篇文章重点介绍了我们对mTOR信号通路的理解的最新进展，以及这些发现对mTOR抑制剂在癌症患者的临床应用的意义。
The immunosuppressive drug rapamycin played a key role in the functional characterization of mammalian target of rapamycin (mTOR), an unusual protein kinase that coordinates growth factor and nutrient availability with cell growth and proliferation. Several rapamycin-related compounds are now in various stages of clinical development as anticancer agents. This article highlights recent advances in our understanding of the mTOR signaling pathway and the implications of these findings for the clinical application of mTOR inhibitors in cancer patients.