Eph receptors and ephrins: therapeutic opportunities.
Eph receptors and ephrins: therapeutic opportunities.
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DOI：
10.1146/annurev-pharmtox-011112-140226
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发表时间：
2015
影响因子：
12.5
通讯作者：
Pasquale EB
中科院分区：
文献类型：
--
作者：
Barquilla A;Pasquale EB
Eph受体酪氨酸激酶家族在发育过程、成体组织稳态和各种疾病中起重要作用。与邻近细胞表面上的肝配蛋白配体的相互作用触发Eph受体激酶依赖性信号传导。肝配蛋白还可以传递信号，导致双向细胞接触依赖性通信。此外，Eph受体和肝配蛋白可以通过与其他信号系统的相互作用相互独立地发挥作用。鉴于它们参与从神经系统疾病到癌症和病毒感染的许多病理状况，Eph受体和肝配蛋白越来越被认为是有吸引力的治疗靶点，并且正在探索各种策略来调节它们的表达和功能。Eph受体/肝配蛋白在癌细胞、血管生成脉管系统和损伤或患病组织中的上调也为基于Eph/肝配蛋白的靶向药物递送和成像提供了机会。因此，尽管Eph受体/肝配蛋白系统的复杂生物学提出了挑战，但利用这些分子的疗法存在令人兴奋的可能性。
The Eph receptor tyrosine kinase family plays important roles in developmental processes, adult tissue homeostasis and various diseases. Interaction with ephrin ligands on the surface of neighboring cells triggers Eph receptor kinase-dependent signaling. The ephrins can also transmit signals, leading to bidirectional cell contact-dependent communication. Moreover, Eph receptors and ephrins can function independently of each other, through interplay with other signaling systems. Given their involvement in many pathological conditions ranging from neurological disorders to cancer and viral infections, Eph receptors and ephrins are increasingly recognized as attractive therapeutic targets and a variety of strategies are being explored to modulate their expression and function. Eph receptor/ephrin upregulation in cancer cells, the angiogenic vasculature, and injured or diseased tissues also offers opportunities for Eph/ephrin-based targeted drug delivery and imaging. Thus, despite the challenges presented by the complex biology of the Eph receptor/ephrin system, exciting possibilities exist for therapies exploiting these molecules.
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影响因子：
6.7
作者：
Chen W;Sin SH;Wen KW;Damania B;Dittmer DP
通讯作者：
Dittmer DP
影响因子：
3.4
作者：
Annunziata, Christina M;Kohn, Elise C;LoRusso, Patricia;Houston, Nicole D;Coleman, Robert L;Buzoianu, Manuela;Robbie, Gabriel;Lechleider, Robert
通讯作者：
Lechleider, Robert
影响因子：
38.3
作者：
通讯作者：
--
DOI：
10.1073/pnas.1119592109
发表时间：
2012-05-08
影响因子：
11.1
作者：
Chakraborty, Sayan;Veettil, Mohanan Valiya;Chandran, Bala
通讯作者：
Chandran, Bala
影响因子：
50.3
作者：
Binda E;Visioli A;Giani F;Lamorte G;Copetti M;Pitter KL;Huse JT;Cajola L;Zanetti N;DiMeco F;De Filippis L;Mangiola A;Maira G;Anile C;De Bonis P;Reynolds BA;Pasquale EB;Vescovi AL
通讯作者：
Vescovi AL