Prostate cancer prevention by nutritional means to alleviate metabolic syndrome
Prostate cancer prevention by nutritional means to alleviate metabolic syndrome
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DOI：
10.1093/ajcn/86.3.889s
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发表时间：
2007-09-01
影响因子：
7.1
通讯作者：
Barnard, R. James
中科院分区：
文献类型：
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作者：
Barnard, R. James
1987年，当瑞文介绍X综合征（代谢综合征或MS）时，我们正在研究骨骼肌胰岛素抵抗，发现当啮齿动物被喂食高脂肪、精制糖（HFS）饮食时，胰岛素抵抗沿着MS的各个方面，包括高胰岛素血症、高血压、高脂血症和肥胖。通过将啮齿动物转换为低脂淀粉饮食来控制啮齿动物中的MS，并通过低脂淀粉饮食和日常锻炼来控制人类中的MS（Pritikin计划）。其他研究报告血清胰岛素和性激素结合球蛋白（SHBG）呈负相关。当受试者被放置在Pritikin计划，胰岛素下降和SHBG上升，它表明，前列腺癌也可能是MS的一个方面。一个生物测定开发与肿瘤细胞系培养和刺激血清之前和之后的饮食和运动干预。饮食和运动改变血清因子，减缓生长速度，诱导雄激素依赖性前列腺癌细胞凋亡。可能重要的饮食和运动引起的血清变化包括胰岛素、雌二醇、胰岛素样生长因子-I（IGF-I）和游离睾酮减少，SHBG和IGF结合蛋白-1增加。高胰岛素血症刺激肝脏产生IGF-I，在促进前列腺癌中起作用，因此是MS和前列腺癌的基石。采用低脂淀粉饮食和日常锻炼可以控制MS，并应降低患前列腺癌的风险。
In 1987 when Reaven introduced syndrome X (metabolic syndrome, or MS), we were studying skeletal muscle insulin resistance and found that when rodents were fed a high-fat, refined-sugar (HFS) diet, insulin resistance developed along with aspects of MS, including hyperinsulinemia, hypertension, hypertriglyceridemia, and obesity. MS was controlled in rodents by switching them to a low-fat, starch diet and was controlled in humans with a low-fat starch diet and daily exercise (Pritikin Program). Others reported inverse relations between serum insulin and sex hormone-binding globulin (SHBG). When subjects were placed on the Pritikin Program, insulin fell and SHBG rose and it was suggested that prostate cancer might also be an aspect of MS. A bioassay was developed with tumor cell lines grown in culture and stimulated with serum before and after a diet and exercise intervention. Diet and exercise altered serum factors that slowed the growth rate and induced apoptosis in androgen-dependent prostate cancer cells. Changes in serum with diet and exercise that might be important include reductions in insulin, estradiol, insulin-like growth factor-I (IGF-I), and free testosterone with increases in SHBG and IGF binding protein-1. Hyperinsulinemia stimulates liver production of IGF-I, plays a role in the promotion of prostate cancer, and thus is the cornerstone for both MS and prostate cancer. Adopting a low-fat starch diet with daily exercise controls MS and should reduce the risk of prostate cancer.