Multiple validated measures of adherence indicate high levels of adherence to generic HIV antiretroviral therapy in a resource-limited setting
Multiple validated measures of adherence indicate high levels of adherence to generic HIV antiretroviral therapy in a resource-limited setting
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DOI：
10.1097/00126334-200408150-00014
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发表时间：
2004-08-15
影响因子：
3.6
通讯作者：
Bangsberg, DR
中科院分区：
文献类型：
--
作者：
Oyugi, JH;Byakika-Tusiime, J;Bangsberg, DR
背景：在资源贫乏的环境中，没有有效的措施来衡量艾滋病毒抗逆转录病毒治疗的依从性。随着艾滋病毒抗逆转录病毒疗法的普及，这些措施对于了解坚持治疗的独特障碍至关重要。30-方法：我们评估了34例购买通用Triomune抗逆转录病毒治疗（共同配制司他夫定、拉米夫定和奈韦拉平; CIPLA，Ltd.，孟买，印度）在乌干达的坎帕拉。措施包括3天的患者自我报告，30天的视觉模拟量表，电子药物监测，和未经通知的家庭药丸计数。HIV-1载量测定在基线和12 weeks.Results：平均依从性为91%-94%的所有措施。76%的受试者的病毒载量为
Background: There are no validated measures of adherence to HIV antiretroviral therapy in resource-poor settings. Such measures are essential to understand the unique barriers to adherence as access to HIV antiretroviral therapy expands. 30-day visual analog scale suggests that this may be the preferred method to assess adherence in resource-poor settings.Methods: We assessed correspondence between multiple measures of adherence and viral load suppression in 34 patients purchasing generic Triomune antiretroviral therapy (coformulated stavudine, lamivudine, and nevirapine; CIPLA, Ltd., Mumbai, India) in Kampala, Uganda. Measures included 3-day patient self-report, 30-day visual analog scale, electronic medication monitoring, and unannounced home pill count. HIV-1 load was determined at baseline and 12 weeks.Results: Mean adherence was 91%-94% by all measures. Seventy-six percent of subjects had a viral load of