Cancer-related fatigue: The scale of the problem
Cancer-related fatigue: The scale of the problem
复制标题
DOI：
10.1634/theoncologist.12-s1-4
复制
发表时间：
2007-01-01
期刊：
影响因子：
5.8
通讯作者：
Morrow, Gary R.
中科院分区：
文献类型：
--
作者：
Hofman, Maarten;Ryan, Julie L.;Morrow, Gary R.
疲劳是癌症患者经历的最常见和使人衰弱的症状之一。癌症相关性疲劳（CRF）的特征在于疲劳，虚弱和缺乏能量的感觉，并且与健康个体经历的“正常”困倦不同，因为它不能通过休息或睡眠来缓解。它既作为癌症本身的结果也作为癌症治疗的副作用而发生，尽管精确的潜在病理生理学在很大程度上是未知的。CRF可能是恶性疾病的早期症状，在诊断时有多达40%的患者报告。几乎所有的患者都期望癌症治疗带来疲劳。高达90%的放射治疗患者和高达80%的化疗患者会感到疲劳。在大约三分之一的癌症患者中，CRF在完成治疗后持续数月甚至数年。CRF对患者生活质量（QoL）的影响，特别是与身体功能和进行日常生活活动的能力相关的影响，既深刻又普遍。此外，CRF与相当大的心理困扰相关，并且可以通过限制患者的工作能力而施加显著的经济负担。这些影响可能延伸到照顾者和家庭成员，他们也可能不得不降低他们的工作能力，以便为CRF患者提供额外的护理。本文探讨了慢性肾功能衰竭的患病率，并探讨了这种令人痛苦的症状对患者的功能和生活质量的影响。
Fatigue is one of the most common and debilitating symptoms experienced by patients with cancer. Cancer-related fatigue (CRF) is characterized by feelings of tiredness, weakness, and lack of energy, and is distinct from the "normal" drowsiness experienced by healthy individuals in that it is not relieved by rest or sleep. It occurs both as a consequence of the cancer itself and as a side effect of cancer treatment, although the precise underlying pathophysiology is largely unknown. CRF may be an early symptom of malignant disease and is reported by as many as 40% of patients at diagnosis. Virtually all patients expect fatigue from cancer therapy. Up to 90% of patients treated with radiation and up to 80% of those treated with chemotherapy experience fatigue. CRF continues for months and even years following completion of treatment in approximately one third of the patients with cancer. The impact of CRF on a patient's quality of life (QoL), particularly in relation to physical functioning and the ability to perform activities of daily living, is both profound and pervasive. In addition, CRF is associated with considerable psychological distress and can impose a significant financial burden by limiting a patient's ability to work. These effects can extend to caregivers and family members, who may also have to reduce their working capacity in order to provide additional care for a patient with CRF. This paper examines the prevalence of CRF and explores the impact of this distressing symptom on patients' functioning and QoL.