Estradiol is a potent protective, restorative, and trophic factor after brain injury.
Estradiol is a potent protective, restorative, and trophic factor after brain injury.
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DOI：
10.1055/s-0029-1216277
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发表时间：
2009-05
影响因子：
2.7
通讯作者：
Wise PM
中科院分区：
文献类型：
--
作者：
Brown CM;Suzuki S;Jelks KA;Wise PM
Estrogens are a group of pleiotropic steroid hormones that exhibit diverse mechanisms of action in multiple physiological systems. Over the past thirty years, biomedical science has begun to appreciate that endogenous estrogens and their receptors display important roles beyond the reproductive system. Our growing appreciation of novel, non-reproductive functions for estrogens has fundamentally contributed to our knowledge of their role in human health and disease. Recent findings from the Women’s Health Initiative have caused clinicians and scientists to question whether estrogens are protective factors or risk factors. In light of the dichotomy between basic science and clinical studies, this review will attempt to reconcile differences between them. We will focus on studies from our laboratory and others highlighting the beneficial properties of the most abundant endogenous estrogen, 17β-estradiol, using in vivo and in vitro models of cerebral ischemia and neuronal injury. These studies demonstrate that 17β-estradiol powerfully protects the brain using multiple molecular mechanisms that promote: 1) decreased cell death, 2) increased neurogenesis, 3) an enhancement of neurotrophic support, and 4) the suppression of pro-inflammatory pathways.
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影响因子：
4.8
作者：
Dubal, Dena B.;Rau, Shane W.;Wise, Phyllis M.
通讯作者：
Wise, Phyllis M.
DOI：
10.1073/pnas.121146898
发表时间：
2001-06-19
影响因子：
11.1
作者：
McEwen, B;Akama, K;Milner, TA
通讯作者：
Milner, TA
影响因子：
3.3
作者：
Lewis, Danielle K.;Johnson, Adam B.;Sohrabji, Farida
通讯作者：
Sohrabji, Farida
影响因子：
5.3
作者：
Jelks, Karen Bozak;Wylie, Rebecca;Wise, Phyllis
通讯作者：
Wise, Phyllis
影响因子：
120.7
作者：
Anderson, GL;Limacher, M;Wassertheil-Smoller, S
通讯作者：
Wassertheil-Smoller, S