Skull Flexure as a Contributing Factor in the Mechanism of Injury in the Rat when Exposed to a Shock Wave
Skull Flexure as a Contributing Factor in the Mechanism of Injury in the Rat when Exposed to a Shock Wave
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DOI：
10.1007/s10439-011-0343-0
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发表时间：
2011-10-01
影响因子：
3.8
通讯作者：
Vandevord, Pamela
中科院分区：
文献类型：
--
作者：
Bolander, Richard;Mathie, Blake;Vandevord, Pamela
爆炸产生的能量是如何传递到大脑中的，目前在冲击伤学界是一个争论不休的话题。本研究旨在探讨冲击波致大鼠神经损伤的生物力学机制。使用颅骨表面的应变计和放置在皮质内的光纤压力传感器测量了冲击波载荷下大鼠头的生物力学响应。应用MicroCT成像技术对颅骨厚度进行量化。应变计结果表明，大鼠头骨的反应取决于入射冲击波的强度；强度越大的冲击波会导致头骨更大的挠度。颅内压传感器显示，脑内形成的峰值压力大于峰值侧面的外部压力，并与表面应变相关。椎板、前缘和中线缝合之间的骨板可能是屈曲最大的区域。这些数据提供了证据，表明颅骨弯曲可能是大鼠大脑内形成颅内压梯度的候选因素。对于使用动物模型研究与爆炸相关的神经损伤的人来说，这种传递压力对特定物种特定头骨动力学的依赖性应该被考虑。
The manner in which energy from an explosion is transmitted into the brain is currently a highly debated topic within the blast injury community. This study was conducted to investigate the injury biomechanics causing blast-related neurotrauma in the rat. Biomechanical responses of the rat head under shock wave loading were measured using strain gauges on the skull surface and a fiber optic pressure sensor placed within the cortex. MicroCT imaging techniques were applied to quantify skull bone thickness. The strain gauge results indicated that the response of the rat skull is dependent on the intensity of the incident shock wave; greater intensity shock waves cause greater deflections of the skull. The intracranial pressure (ICP) sensors indicated that the peak pressure developed within the brain was greater than the peak side-on external pressure and correlated with surface strain. The bone plates between the lambda, bregma, and midline sutures are probable regions for the greatest flexure to occur. The data provides evidence that skull flexure is a likely candidate for the development of ICP gradients within the rat brain. This dependency of transmitted stress on particular skull dynamics for a given species should be considered by those investigating blast-related neurotrauma using animal models.