Computational fluid dynamics analysis and experimental hemolytic performance of three clinical centrifugal blood pumps: Revolution, Rotaflow and CentriMag.
Computational fluid dynamics analysis and experimental hemolytic performance of three clinical centrifugal blood pumps: Revolution, Rotaflow and CentriMag.
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DOI：
10.1016/j.medntd.2022.100153
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发表时间：
2022-09-01
影响因子：
--
通讯作者：
Wu, Zhongjun J
中科院分区：
文献类型：
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作者：
Han, Dong;Leibowitz, Joshua L;Wu, Zhongjun J
离心血泵因其卓越的血液处理能力和避免停滞区域的二次流路而降低血栓形成风险，在成人体外膜肺氧合 (ECMO) 中广受欢迎。然而，离心血泵内的高转速会引入高剪切应力，导致显着的剪切引起的溶血率。 Revolution 泵、Rotaflow 泵和 CentriMag 泵是市场上三种领先的离心血泵。尽管许多实验和计算研究都集中于评估 Rotaflow 和 CentriMag 泵的水力和溶血性能，但很少有关于 Revolution 泵的研究。此外，无法对这三种泵的流量特性和溶血进行彻底的直接比较。在本研究中，我们进行了计算和实验分析，以比较在临床相关条件下运行的 Revolution、Rotaflow 和 CentriMag 泵的溶血性能，即血流量 5 L/min 和泵压头 350 mmHg，用于成人 ECMO 支持。计算机模拟用于表征剪切应力分布并预测溶血指数，而体外血液循环研究则通过实验确定溶血性能。比较模拟结果和实验数据表明，CentriMag 泵引起的溶血最低，而 Revolution 泵产生的溶血最高。
Centrifugal blood pumps have become popular for adult extracorporeal membrane oxygenation (ECMO) due to their superior blood handling and reduced thrombosis risk featured by their secondary flow paths that avoid stagnant areas. However, the high rotational speed within a centrifugal blood pump can introduce high shear stress, causing a significant shear-induced hemolysis rate. The Revolution pump, the Rotaflow pump, and the CentriMag pump are three of the leading centrifugal blood pumps on the market. Although many experimental and computational studies have focused on evaluating the hydraulic and hemolytic performances of the Rotaflow and CentriMag pumps, there are few on the Revolution pump. Furthermore, a thorough direct comparison of these three pumps' flow characteristics and hemolysis is not available. In this study, we conducted a computational and experimental analysis to compare the hemolytic performances of the Revolution, Rotaflow, and CentriMag pumps operating under a clinically relevant condition, i.e., the blood flow rate of 5 L/min and pump pressure head of 350 mmHg, for adult ECMO support. In silico simulations were used to characterize the shear stress distributions and predict the hemolysis index, while in vitro blood loop studies experimentally determined hemolysis performance. Comparative simulation results and experimental data demonstrated that the CentriMag pump caused the lowest hemolysis while the Revolution pump generated the highest hemolysis.