Executive function and cognitive subprocesses in first-episode, drug-naive schizophrenia: An analysis of N-back performance
Executive function and cognitive subprocesses in first-episode, drug-naive schizophrenia: An analysis of N-back performance
复制标题
DOI：
10.1176/appi.ajp.162.6.1206
复制
发表时间：
2005-06-01
影响因子：
17.7
通讯作者：
Meyer-Lindenberg, A
中科院分区：
文献类型：
--
作者：
Krieger, S;Lis, S;Meyer-Lindenberg, A
目的：本研究探讨了精神分裂症患者N-back操作的认知结构的变化。方法：采用反应时分解范式，对12例首发精神分裂症患者和12例未服药精神分裂症患者的N-back操作进行了研究。反应时间分解表明减缓的visuality和选择反应处理，以及无法平行处理工作memory.Discussion：虽然N-回任务有效地访问工作记忆功能作为一种神经认知特征的疾病，几个额外的子过程和认知并行处理的能力被改变，需要进一步研究精神分裂症。
Objective: This study investigated changes in the cognitive architecture of N-back performance in schizophrenia.Method: N-back performance of 12 patients with first-episode, drug-naive schizophrenia and matched healthy comparison subjects was studied in a reaction-time decomposition paradigm.Results: Imposition of a working memory load led to a significant drop in response accuracy in patients. Reaction-time decomposition suggested slowing of visuomotor and choice reaction processing as well as an inability of parallel processing directed by working memory.Discussion: Although N-back tasks validly access working memory function as a neurocognitive trait in the illness, several additional subprocesses and the ability for cognitive parallel processing are altered and require further study in schizophrenia.